NCT05498337

Brief Summary

This study will be conducted to: Evaluate clinically and radiographically apexogenesis in immature permanent molars using:

  1. 1.Calcium Hydroxide.
  2. 2.MTA.
  3. 3.Laser.
  4. 4.Laser combined with MTA.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2022

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 10, 2022

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 12, 2022

Completed
20 days until next milestone

Study Start

First participant enrolled

September 1, 2022

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2023

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2024

Completed
Last Updated

October 2, 2025

Status Verified

September 1, 2025

Enrollment Period

1.1 years

First QC Date

August 10, 2022

Last Update Submit

September 27, 2025

Conditions

Vital Pulp Therapy

Keywords

AlpexogenesisMTACalcium hydroxideDiode Laser

Outcome Measures

Primary Outcomes (1)

  • Root completion

    Closure of radiographic apex using Scanora 5.2.6 digital software

    one year

Secondary Outcomes (1)

  • Root lengthening and thickening

    one year

Other Outcomes (1)

  • Clinical evaluation

    one year

Study Arms (2)

Examiner

OTHER

Examiner

Other: calcium hydroxideOther: MTADevice: Diode Laser

Patient

NO INTERVENTION

Patient

Interventions

calcium hydroxideOTHER

Dental pulp medicament material

Examiner
MTAOTHER

Dental pulp medicament material

Examiner
Diode LaserDEVICE

Device used in pulp therapy

Examiner

Eligibility Criteria

Age7 Years - 9 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Medically free
  • Vital teeth

You may not qualify if:

  • Medically compromised
  • Chronic abscess
  • Non-vital teeth

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Mansoura University

Al Mansurah, Dakhalia Governrate, 35516, Egypt

Location

MeSH Terms

Interventions

Calcium HydroxidePemetrexedLasers, Semiconductor

Intervention Hierarchy (Ancestors)

HydroxidesAlkaliesInorganic ChemicalsCalcium CompoundsAnionsIonsElectrolytesGuanineHypoxanthinesPurinonesPurinesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic CompoundsGlutamatesAmino Acids, AcidicAmino AcidsAmino Acids, Peptides, and ProteinsAmino Acids, DicarboxylicLasersOptical DevicesEquipment and SuppliesRadiation Equipment and Supplies

Study Officials

  • Salwa M Awad, Professor

    Mansoura University

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant lecturer

Study Record Dates

First Submitted

August 10, 2022

First Posted

August 12, 2022

Study Start

September 1, 2022

Primary Completion

September 30, 2023

Study Completion

April 1, 2024

Last Updated

October 2, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will not share

Locations

EG(1)