Comparison of Mechanical Power Calculations of Volume Control and Pressure Control Modes

NCT05494554 | Completed

• 1 other identifier: 2019-02-23
• Study Type: observational
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

The management of ARDS, which is one of the important problems of intensive care patients, has gained popularity with the pandemic. Mechanical ventilation is an important life-saving treatment in ARDS patients. However, when not used correctly, it can cause Ventilator-Induced Lung Injury (VILI). Therefore, lung protective ventilation should be applied to minimize VILI in ARDS patients. Mechanical power is one of the parameters that guides intensivist in predicting VILI.

Conditions

Ventilator-Induced Lung Injury

Outcome Measures

Primary Outcomes (1)

• Mechanical power values of different ventilation modes

  We aimed to compare the volume control and pressure control modes over the mechanical power values.

  60 minutes

Study Arms (2)

Pressure control mode group

On the 2nd day of intensive care hospitalization, while under deep sedation and in the controlled mode (VCV or PRVC) and in the supine position, the ventilator in the VCV mode was switched to PRVC mode for 60 minutes without changing any of the set ventilator settings (RR, PEEP, TV, I:E ratio).

Device: Changing mechanical ventilation mode

Volume control mode group

Likewise, if it is in PRVC mode, it is also switched to VCV mode for 60 minutes. In this way, two dependent groups were formed.

Device: Changing mechanical ventilation mode

Interventions

Changing mechanical ventilation mode DEVICE

On the 2nd day of intensive care hospitalization, while under deep sedation and in the controlled mode (VCV or PRVC) and in the supine position, the ventilator in the VCV mode was switched to PRVC mode for 60 minutes without changing any of the set ventilator settings (RR, PEEP, TV, I:E ratio). Likewise, if it is in PRVC mode, it is also switched to VCV mode for 60 minutes. MP values were calculated from the minute respiratory parameters of all patients with the MP formulas defined in the software.

Pressure control mode group; Volume control mode group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study was conducted prospectively with 36 Covid-19 ARDS patients who were followed up in the Dr. Sadi Konuk Training and Research Hospital Anesthesia and Intensive Care Unit and diagnosed with ARDS according to the Berlin criteria. The definite COVID-19 diagnosis was confirmed by PCR (Bio-Speedy Covid-19 RT-Qpcr detection Kit-Bioeksen, Turkey) obtained from the nasal swab sample and chest computed tomography images.

You may qualify if:

• Patients with confirmed Covid-19 diagnosis in intensive care unit (ICU) and diagnosed with ARDS according to Berlin criteria
• Intubated patients which treated in the supine position on the second day of ICU admission

You may not qualify if:

• Patients with a known diagnosis of COPD
• Patients experiencing hemodynamic instability during ventilation
• Prone pozisyonda olan hastalar
• Patients receiving inotropic support
• Patients with missing data

Sponsors & Collaborators

• Bakirkoy Dr. Sadi Konuk Research and Training Hospital: lead

Study Sites (1)

Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Ventilator-Induced Lung Injury

Condition Hierarchy (Ancestors)

Lung Injury; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Furkan Tontu

  Intensivist

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 21, 2022
• First Posted: August 10, 2022
• Study Start: January 1, 2020
• Primary Completion: December 27, 2021
• Study Completion: January 22, 2022
• Last Updated: August 10, 2022

Record last verified: 2022-08

Locations

TU (1)