ITGA2b and SELP Expression in Cancer Pancreas and Biliary Tract Cancer

NCT05493878 | Unknown

• 1 other identifier: TEPs genes in cancer pancrease
• Study Type: observational
• Target: 128
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.To study the expression pattern of Integrin alpha 2b (ITGA2b) and Selectin P (SELP) genes of Tumor educated platelets in pancreatic and biliary tree cancer and its diagnostic value.
2. 2.To investigate correlation between expression levels of ITGA2b and SELP genes and stages of pancreatic and biliary tree cancer.
3. 3.To investigate correlation between expression levels of ITGA2b, SELP genes, CA 19-9 and CEA in pancreatic and biliary tree cancer patients.

Conditions

Pancreas Cancer

Keywords

ITGA2b; SELP; Tumor educated platelets

Outcome Measures

Primary Outcomes (1)

• Expression levels of ITGA2b and SELP on Tumor Educated PLatelets for diagnosis of pancreatic and biliary cancer

  To study the expression pattern of ITGA2b and SELP genes of Tumor educated platelets in pancreatic and biliary tree cancer and its diagnostic value.

  Baseline

Secondary Outcomes (1)

• Correlation between expression levels of ITGA2b and SELP on TEPs and the commonly used tumour marker CEA and CA 19-9 in the diagnosis of pancreatic and biliary cancer.

  Baseline

Interventions

mRNA expression DIAGNOSTIC_TEST

Tumor educated platelets ITGA2b and SELP mRNA by reverse transcription-quantitative polymerase chain reaction (RT-qPCR).

Also known as: gene expression, ITGA2b, SELP

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will be conducted at clinical pathology department, Assiut University Hospital, Faculty of medicine, Assiut University. Patient will be recruited from out patient clinics and in patients of the oncology department in Assiut university. Patients diagnosed pathologically as pancreatic and biliary cancer by gold standard test (pancreatic and biliary tract biopsy by endoscopy), male or female at any age

You may qualify if:

• Patients diagnosed pathologically as pancreatic and biliary cancer by gold standard test (pancreatic and biliary tract biopsy by endoscopy), male or female at any age.

You may not qualify if:

• History of anti-neoplastic therapy, such as chemotherapy or radiotherapy.
• Any other types of cancers.
• Any other clinically systemic acute or chronic inflammatory disease/s within one months.
• Autoimmune diseases.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• Xing S, Zeng T, Xue N, He Y, Lai YZ, Li HL, Huang Q, Chen SL, Liu WL. Development and Validation of Tumor-educated Blood Platelets Integrin Alpha 2b (ITGA2B) RNA for Diagnosis and Prognosis of Non-small-cell Lung Cancer through RNA-seq. Int J Biol Sci. 2019 Jul 24;15(9):1977-1992. doi: 10.7150/ijbs.36284. eCollection 2019.

  PMID: 31523198 BACKGROUND

• D'Ambrosi S, Nilsson RJ, Wurdinger T. Platelets and tumor-associated RNA transfer. Blood. 2021 Jun 10;137(23):3181-3191. doi: 10.1182/blood.2019003978.

  PMID: 33940602 BACKGROUND

• D'Ambrosi S, Visser A, Antunes-Ferreira M, Poutsma A, Giannoukakos S, Sol N, Sabrkhany S, Bahce I, Kuijpers MJE, Oude Egbrink MGA, Griffioen AW, Best MG, Koppers-Lalic D, Oudejans C, Wurdinger T. The Analysis of Platelet-Derived circRNA Repertoire as Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer. Cancers (Basel). 2021 Sep 16;13(18):4644. doi: 10.3390/cancers13184644.

  PMID: 34572871 BACKGROUND

MeSH Terms

Conditions

Pancreatic Neoplasms

Interventions

Gene Expression

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Genetic Phenomena

Study Officials

• Ola A Afifi, doctor

  Ola A Afifi

  STUDY DIRECTOR

• Fatma M Helbawi, doctor

  Fatma M Helbawi

  STUDY CHAIR

Central Study Contacts

Amany H Radwan, doctor

CONTACT

00201116859359; amany.hamdy91@yahoo.com

Aml A Rayan, doctor

CONTACT

00201002286687; amladel_137@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: August 7, 2022
• First Posted: August 9, 2022
• Study Start: March 1, 2023
• Primary Completion: March 1, 2024
• Study Completion: May 1, 2024
• Last Updated: August 9, 2022

Record last verified: 2022-08