Contingency Management to Promote Smoking Abstinence in Cancer Patients

NCT04605458 | Completed

• 2 other identifiers: 00099446R01CA251158-01
• Study Type: interventional
• Target: 282
• Locations: 1 country
• Sites: 1

Brief Summary

This is a smoking cessation treatment study. Patients who have a cancer or a suspected cancer who will undergo surgical removal of their cancer are eligible to participate in this study. A novel smoking cessation treatment will be provided to half of the participants in the study. All study participants will receive standard smoking cessation therapy including counseling and the nicotine patch.

Conditions

Smoking Cessation

Outcome Measures

Primary Outcomes (1)

• Abstinence Rates as assessed by self-report for past 7 days, Carbon Monoxide Breath Monitoring and/or Anabasine testing

  Abstinence will be defined by 7 days by self-report of no tobacco products, confirmed by CO breath test less than or equal to 4ppm and/or urine anabasine levels less than or equal to 2 ng/ml

  Changes between the study intake appointment to day of surgery, up to five weeks apart

Secondary Outcomes (1)

• Abstinence Rates as assessed by self-report for past 7 days, Carbon Monoxide Breath Monitoring and/or Anabasine testing

  Three and Six months after surgery date

Study Arms (2)

Contingency Management

EXPERIMENTAL

Combination Product: Contingency Management

Standard Care

ACTIVE COMPARATOR

Combination Product: Standard Care

Interventions

Contingency Management COMBINATION_PRODUCT

Participants will receive 3-6 counseling sessions, nicotine patches \& lozenges, and monetary payment delivered contingent on abstinence verified by CO breath test.

Contingency Management

Standard Care COMBINATION_PRODUCT

Participants will receive 3-6 counseling sessions, nicotine patches \& lozenges, and CO breath test monitoring.

Standard Care

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 or older
• smoking 1 or more combustible tobacco products per day
• diagnosed with or suspicion of any type of operable cancer

You may not qualify if:

• unstable psychiatric/medical conditions such as suicidal ideation, acute psychosis, or dementia
• non-English speaking
• use of alternative nicotine delivery systems (e.g., e-cigarettes, snus, etc)
• pregnant women

Sponsors & Collaborators

• Medical University of South Carolina: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

Location

Related Publications (1)

• Rojewski AM, Fucito LM, Baker NL, Palmer AM, Foster MG, Warren GW, Bernstein SL, Toll BA. Preoperative contingency management intervention for smoking abstinence in cancer patients: trial protocol for a multisite randomised controlled trial. BMJ Open. 2021 Jun 29;11(6):e051226. doi: 10.1136/bmjopen-2021-051226.

  PMID: 34187835 DERIVED

MeSH Terms

Conditions

Smoking Cessation

Interventions

Standard of Care

Condition Hierarchy (Ancestors)

Health Behavior; Behavior

Intervention Hierarchy (Ancestors)

Quality Indicators, Health Care; Quality of Health Care; Health Services Administration; Health Care Quality, Access, and Evaluation

Study Officials

• Benjamin Toll

  Medical University of South Carolina

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 25, 2020
• First Posted: October 28, 2020
• Study Start: November 25, 2020
• Primary Completion: July 10, 2025
• Study Completion: December 18, 2025
• Last Updated: March 5, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)