Interactive Hand Exercise Game on Grip Strength and Vascular Maturation

NCT05493046 | Completed

• 1 other identifier: 22MMHIS083e
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Hemodialysis is currently the most commonly used renal replacement therapy. Compared with arteriovenous graft, central venous catheter, and autologous arteriovenous fistula, the possibility of postoperative re-dredging is low and there are few complications, so isometric hand exercise training is the first choice for hemodialysis strategy. The intervention of smart technology has greatly improved the treatment effect and quality of life of patients, and it has unique advantages when applied to health care or behavior change intervention programs. This study expects to enhance hand grip strength through interactive hand exercise games combined with grip strength equipment, thereby increasing the vascular maturity of patients with postoperative autologous arteriovenous fistula, and enhancing the motivation of patients to participate.

Conditions

Muscle Weakness; Angiogenesis

Keywords

Hand-grip Strength; Hemodialysis

Outcome Measures

Primary Outcomes (3)

• Changes in vein diameter

  This will be measured by using duplex ultrasound. The maturation of autologous arteriovenous fistula is defined as a cross-sectional luminal diameter of the draining vein \>6 mm.

  The 1th week, the 4th weeks and the 8th weeks after the autologous arteriovenous fistula surgery

• Changes in the depth of the fistula from the epidermis

  The depth of the fistula from the epidermis is measured using duplex ultrasound. The maturation of autologous arteriovenous fistula should be \<0.6 cm from the epidermis.

  The 1th week, the 4th weeks and the 8th weeks after the autologous arteriovenous fistula operation.

• Changes in brachial artery blood flow rate

  The flow rate is measured using duplex ultrasound. The maturation of autologous arteriovenous fistula is defined as a flow velocity in the artery \>600 ml/min.

  The 1th week, the 4th weeks and the 8th weeks after the autologous arteriovenous fistula operation.

Secondary Outcomes (1)

• Changes in grip strength

  The 1th week, the 4th weeks and the 8th weeks after the autologous arteriovenous fistula operation.

Study Arms (2)

Interactive Hand Exercise Game

EXPERIMENTAL

Participants will receive an Interactive Hand Exercise Game for 30 minutes every day for consecutive two months.

Behavioral: Interactive Hand Exercise Game

Soft ball exercise ( routine care)

ACTIVE COMPARATOR

Participants will receive a soft ball exercise for 30 minutes every day for consecutive two months.

Behavioral: Soft ball exercise ( routine care)

Interventions

Interactive Hand Exercise Game BEHAVIORAL

Interactive Hand Exercise Game to Improve Vascular Maturity and Grip Strength in Patients undergoing Arteriovenous Fistula Surgery

Interactive Hand Exercise Game

Soft ball exercise ( routine care) BEHAVIORAL

Soft ball exercise ( routine care)

Soft ball exercise ( routine care)

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical diagnosis of chronic renal failure stage 4 to 5 (before dialysis) and stage 5 (patients who have started hemodialysis).
• Newly established surgical patients with autologous arteriovenous fistula.
• Aged between 20 and 70 years old.
• Having clear consciousness and being able to communicate in Chinese.

You may not qualify if:

• Previous dysfunction of an autologous arteriovenous fistula in the same arm.
• Injury to the fistula extremity.
• Neuromusculoskeletal abnormalities.
• Upper extremity arthritis.
• Peripheral neuropathy.
• Peripheral arterial dysfunction.
• Venous disease.
• Rheumatic disease.

Sponsors & Collaborators

• Taipei Medical University: lead
• Mackay Memorial Hospital: collaborator

Study Sites (1)

Hsiao-Yean Chiu

Taipei, 110, Taiwan

Location

Related Publications (1)

• Luo YC, Han PH, Chen YY, Wu PC, Wu IW, Fan YC, Chiu HY. Effects of Interactive Handgrip Game on Vascular Maturation and Grip Strength in Patients Undergoing Arteriovenous Fistula Surgery: A Feasibility Randomized Controlled Trial. Hemodial Int. 2026 Jan 1. doi: 10.1111/hdi.70045. Online ahead of print.

  PMID: 41479242 DERIVED

MeSH Terms

Conditions

Muscle Weakness

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Chiu Hsiao-Yean, PhD

  Taipei Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Outcomes assessor will be unaware of the treatment assignment before the completion of the study
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 4, 2022
• First Posted: August 9, 2022
• Study Start: August 10, 2022
• Primary Completion: November 20, 2024
• Study Completion: November 20, 2024
• Last Updated: August 15, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)