Florida Cerebrovascular Disease Biorepository and Genomics Center

NCT05491980 | Active Not Recruiting

• 1 other identifier: 22-002667
• Study Type: observational
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by cerebrovascular disease. The information and blood samples collected may be used in future research for the study of cerebrovascular disease and to learn about, prevent or treat other health problems.

Conditions

Cerebrovascular Disease; Ischemic Stroke; Transient Ischemic Attack; Intracerebral Hemorrhage; Aneurysmal Subarachnoid Hemorrhage; Vascular Dementia; Anoxic Brain Injury; Unruptured Intracranial Aneurysm; Carotid Artery Stenosis Symptomatic; Asymptomatic Carotid Artery Stenosis; Non-Aneurysmal Perimesencephalic Subarachnoid Haemorrhage; Cerebral Venous Thrombosis; Moyamoya Disease; Fibromuscular Dysplasia; Subarachnoid Hemorrhage; Leukoaraiosis; Arteriovenous Fistula; Reversible Cerebral Vasoconstriction Syndrome; CADASIL

Outcome Measures

Primary Outcomes (1)

• Stroke or TIA at 12 months

  Number of participants to experience new diagnosis of TIA or stroke.

  1 year

Secondary Outcomes (1)

• Modified Rankin Scale

  1 year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects identified with a history of cerebrovascular disease will be recruited from both the in-patient and outpatient services at Mayo Clinic Florida.

You may qualify if:

• Affected subjects with diverse cerebrovascular conditions, including, but not limited to, ischemic stroke, transient ischemic attack (TIA), intracerebral hemorrhage (ICH), aneurysmal subarachnoid hemorrhage (aSAH), vascular dementia (VAD), anoxic brain injury, unruptured intracranial aneurysm (UIA), cavernous malformation, arteriovenous malformations (AVM), carotid and vertebral arterial dissections, symptomatic and asymptomatic cervical carotid artery atherosclerotic stenosis, non-aneurysmal perimesencephalic subarachnoid hemorrhage (naSAH), cerebral venous thrombosis (CVT), moyamoya disease, fibrosmuscular dysplasia (FMD), non-traumatic, angiography-negative subarachnoid hemorrhage, leukoaraiosis, arteriovenous fistula, reversible cerebral vasoconstriction syndrome (RCVS), and CADASIL.

You may not qualify if:

• All patients with the following known or suspected virulent microorganisms causing an active or latent infection will be excluded from the study:
• Human immunodeficiency virus (HIV);
• Any viral hepatitis;
• West Nile virus (WNV);
• Influenza virus;
• Tuberculosis (TB);
• Any bacteremia;
• Any fungemia;
• Any prionopathy.

Sponsors & Collaborators

• Mayo Clinic: lead

Study Sites (1)

Mayo Clinic Florida

Jacksonville, Florida, 32224, United States

Location

Related Links

• Mayo Clinic Clinical Trials

MeSH Terms

Conditions

Cerebrovascular Disorders; Ischemic Stroke; Ischemic Attack, Transient; Cerebral Hemorrhage; Subarachnoid Hemorrhage; Dementia, Vascular; Hypoxia-Ischemia, Brain; Intracranial Thrombosis; Moyamoya Disease; Fibromuscular Dysplasia; Leukoaraiosis; Arteriovenous Fistula; CADASIL

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Stroke; Brain Ischemia; Intracranial Hemorrhages; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Intracranial Arteriosclerosis; Intracranial Arterial Diseases; Dementia; Leukoencephalopathies; Arteriosclerosis; Arterial Occlusive Diseases; Neurocognitive Disorders; Mental Disorders; Hypoxia, Brain; Hypoxia; Signs and Symptoms, Respiratory; Signs and Symptoms; Intracranial Embolism and Thrombosis; Thromboembolism; Embolism and Thrombosis; Carotid Artery Diseases; Cerebral Arterial Diseases; Arteriovenous Malformations; Vascular Malformations; Cardiovascular Abnormalities; Vascular Fistula; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Fistula; Pathological Conditions, Anatomical; Cerebral Infarction; Brain Infarction; Cerebral Small Vessel Diseases; Genetic Diseases, Inborn; Infarction; Ischemia; Necrosis

Study Officials

• James Meschia, MD

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 5, 2022
• First Posted: August 8, 2022
• Study Start: August 2, 2022
• Primary Completion: April 1, 2026
• Study Completion: April 1, 2026
• Last Updated: March 23, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)