Effects of Vitamin D on Skeletal Muscle Strength in Resistance Trained Adult Females

NCT05489666 | Unknown

• 1 other identifier: 22-306
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

The majority of vitamin D research has been done in non-athletic populations, particularly older populations, to analyze muscle weakness, pain, balance, and fractures. It has been reported that over a billion people worldwide are vitamin D deficient, including 36-70% of the young adult population. Previous literature also suggests that, even among healthy athletes, over 50% of subjects sampled had inadequate or insufficient vitamin D levels. Vitamin D deficiency can occur in young women, including pregnant women, and the risk of deficiency is even higher with advancing age in a woman's lifecycle. It is known that preserving skeletal muscle (SM) function is critical for women of all ages to prevent sarcopenia. Two factors in preserving SM are protein intake and resistance training. Relatively unknown are the actions of Vitamin D on SM function. Vitamin D deficiency can have a negative effect on SM function . However, additional research is needed to investigate the increase in SM strength when the serum concentration of vitamin D is improved. It is possible that an athlete may require an increased intake of vitamin D to assure adequate availability and storage for optimal performance; however, is known that food sources of vitamin D are limited in sufficient quantity to meet these requirements. Athletes who are insufficient will require a supplement of vitamin D3 for up to 5000 IU/day for at least eight weeks, to potentially reach optimal levels, then 1000-2000 IU/day for maintenance.

Conditions

Nutrition Status; Nutritional Requirements; Sports Nutritional Sciences

Keywords

Nutrition; Supplement; Supplementation; Vitamin D; Strength Training; Resistance Training; Women; Female; Athlete

Outcome Measures

Primary Outcomes (1)

• Biodex Strength performance change

  Taking a daily supplement of 5,000 IU of vitamin D3 may change strength outcomes measured in newton meters (Nm).

  8 weeks

Secondary Outcomes (1)

• Serum 25(OH)D status

  8 weeks

Study Arms (2)

Treatment Group

ACTIVE COMPARATOR

Participants in this group will be administered an oral Vitamin D3 supplement; 5,000 IU/ day. The participants will take the supplement themselves, orally, once per day, for 8 weeks.

Dietary Supplement: Nature Made Vitamin D3 5,000 IU, 125mcg

Control Group

PLACEBO COMPARATOR

Participants in this group will be administered an oral, soft-gel, lookalike placebo. The participants will take the supplement themselves, orally, once per day, for 8 weeks.

Dietary Supplement: Placebo

Interventions

Nature Made Vitamin D3 5,000 IU, 125mcg DIETARY_SUPPLEMENT

Taking a 5,000 IU oral supplement of Vitamin D3, daily, for 8 weeks, may improve strength performance in women who have and are continuing a resistance trained workout regimen. After blood vitamin D levels have been raised to an optimal range, a lower dosage may be assigned as needed from 5,000 IU per day to 1,000-2,000 IU per day.

Also known as: Spring Valley, Life Extensions, GNC, Nature's Bounty, CVSHealth, Swanson

Treatment Group

Placebo DIETARY_SUPPLEMENT

Resistance trained women may not improve their strength performance with low levels of vitamin D in the blood.

Control Group

Eligibility Criteria

• Age: 19 Years - 55 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participant will need to answer "yes" to the following items:
• female
• not pregnant
• between the ages of 19-55 years old
• a non-smoker
• currently resistance training (i.e., lifting weights) for more than 2 days/week for a minimum of \> 24 months
• free of any known overt cardiovascular or metabolic disease
• not an active user of tanning beds
• not consuming now or haven't consumed within the last 6 months, a vitamin D or multivitamin supplement or a form of a supplement with vitamin D added
• not consuming now or haven't consumed within the last 2 months, agents that affect hormones (testosterone boosters, growth hormone boosters, etc.) (does not include birth control/oral contraceptives)
• not allergic to rubbing alcohol

Sponsors & Collaborators

• Auburn University: lead

Related Publications (12)

• Abrams GD, Feldman D, Safran MR. Effects of Vitamin D on Skeletal Muscle and Athletic Performance. J Am Acad Orthop Surg. 2018 Apr 15;26(8):278-285. doi: 10.5435/JAAOS-D-16-00464.

  PMID: 29561306 RESULT

• Bartoszewska M, Kamboj M, Patel DR. Vitamin D, muscle function, and exercise performance. Pediatr Clin North Am. 2010 Jun;57(3):849-61. doi: 10.1016/j.pcl.2010.03.008.

  PMID: 20538161 RESULT

• Chiang CM, Ismaeel A, Griffis RB, Weems S. Effects of Vitamin D Supplementation on Muscle Strength in Athletes: A Systematic Review. J Strength Cond Res. 2017 Feb;31(2):566-574. doi: 10.1519/JSC.0000000000001518.

  PMID: 27379960 RESULT

• Dahlquist DT, Dieter BP, Koehle MS. Plausible ergogenic effects of vitamin D on athletic performance and recovery. J Int Soc Sports Nutr. 2015 Aug 19;12:33. doi: 10.1186/s12970-015-0093-8. eCollection 2015.

  PMID: 26288575 RESULT

• Han Q, Li X, Tan Q, Shao J, Yi M. Effects of vitamin D3 supplementation on serum 25(OH)D concentration and strength in athletes: a systematic review and meta-analysis of randomized controlled trials. J Int Soc Sports Nutr. 2019 Nov 26;16(1):55. doi: 10.1186/s12970-019-0323-6.

  PMID: 31771586 RESULT

• Knechtle B, Nikolaidis PT. Vitamin D and Sport Performance. Nutrients. 2020 Mar 21;12(3):841. doi: 10.3390/nu12030841.

  PMID: 32245151 RESULT

• Ksiazek A, Zagrodna A, Slowinska-Lisowska M. Vitamin D, Skeletal Muscle Function and Athletic Performance in Athletes-A Narrative Review. Nutrients. 2019 Aug 4;11(8):1800. doi: 10.3390/nu11081800.

  PMID: 31382666 RESULT

• Ogan D, Pritchett K. Vitamin D and the athlete: risks, recommendations, and benefits. Nutrients. 2013 May 28;5(6):1856-68. doi: 10.3390/nu5061856.

  PMID: 23760056 RESULT

• Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int. 2011 Mar;22(3):859-71. doi: 10.1007/s00198-010-1407-y. Epub 2010 Oct 6.

  PMID: 20924748 RESULT

• Tomlinson PB, Joseph C, Angioi M. Effects of vitamin D supplementation on upper and lower body muscle strength levels in healthy individuals. A systematic review with meta-analysis. J Sci Med Sport. 2015 Sep;18(5):575-80. doi: 10.1016/j.jsams.2014.07.022. Epub 2014 Aug 11.

  PMID: 25156880 RESULT

• Wicinski M, Adamkiewicz D, Adamkiewicz M, Sniegocki M, Podhorecka M, Szychta P, Malinowski B. Impact of Vitamin D on Physical Efficiency and Exercise Performance-A Review. Nutrients. 2019 Nov 19;11(11):2826. doi: 10.3390/nu11112826.

  PMID: 31752277 RESULT

• de la Puente Yague M, Collado Yurrita L, Ciudad Cabanas MJ, Cuadrado Cenzual MA. Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends. Nutrients. 2020 Feb 23;12(2):579. doi: 10.3390/nu12020579.

  PMID: 32102188 RESULT

Study Officials

• Donna O Burnett, PhD

  Auburn University

  STUDY CHAIR

Central Study Contacts

Nilophar L Zandieh, MS

CONTACT

9492447504; nlz0005@auburn.edu

Donna O Burnett, PhD

CONTACT

334-844-3429; dob0002@auburn.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Double-blind masking; neither the investigator nor the participants will know, the assigned intervention placement.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Model Details: A two-arm parallel assignment; one group receives the treatment (vitamin D3 supplement 5,000IU/day) and one group receives the placebo (control).

Study Record Dates

• First Submitted: August 3, 2022
• First Posted: August 5, 2022
• Study Start: September 1, 2022
• Primary Completion: November 30, 2022
• Study Completion: February 1, 2023
• Last Updated: August 10, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share