Safety and Efficacy of Hs-cTnT Protocols
1 other identifier
observational
1,167
0 countries
N/A
Brief Summary
Chest pain is a common presenting complaint among patients in the emergency department (ED). A large portion of patients with chest pain undergo lengthy assessment in the ED or are admitted to rule out acute oronary syndrome (ACS), often with stress testing, creating a substantial health care burden. The new high-sensitivity cardiac troponin assays allow use of shorter time intervals for repeated blood samples and may improve care for chest pain patients. The aim of this cohort is to evaluate high-sentivity troponin based protocols for ruling out and ruling in ACS in the ED.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2013
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
April 30, 2014
CompletedFirst Submitted
Initial submission to the registry
July 31, 2022
CompletedFirst Posted
Study publicly available on registry
August 2, 2022
CompletedNovember 18, 2023
September 1, 2022
1.2 years
July 31, 2022
November 14, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
30-day MACE
MACE within 30 days including the index visit. MACE was defined as an adjudicated diagnosis of AMI, UA, cardiac arrest, cardiogenic shock, ventricular arrhythmia requiring intervention, atrioventricular block requiring intervention, or death of a cardiac or unknown cause
30 days
Secondary Outcomes (1)
30-day MACE without UA
30 days
Interventions
Collection of hs-cTnT samples
Eligibility Criteria
Consecutive ED chest pain patients
You may qualify if:
- \>=18 years of age
- Presented to the ED with non-traumatic chest pain/discomfort
- Hs-cTnT testing was ordered at presentation
You may not qualify if:
- STEMI at presentation
- Severe communication barriers
- Hemolysis with a hemoglobin concentration\>0.1 g/dl, H-index\>=100
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Region Skanelead
Related Publications (2)
Mokhtari A, Borna C, Gilje P, Tyden P, Lindahl B, Nilsson HJ, Khoshnood A, Bjork J, Ekelund U. A 1-h Combination Algorithm Allows Fast Rule-Out and Rule-In of Major Adverse Cardiac Events. J Am Coll Cardiol. 2016 Apr 5;67(13):1531-1540. doi: 10.1016/j.jacc.2016.01.059.
PMID: 27150684BACKGROUNDNeumann JT, Twerenbold R, Ojeda F, Aldous SJ, Allen BR, Apple FS, Babel H, Christenson RH, Cullen L, Di Carluccio E, Doudesis D, Ekelund U, Giannitsis E, Greenslade J, Inoue K, Jernberg T, Kavsak P, Keller T, Lee KK, Lindahl B, Lorenz T, Mahler SA, Mills NL, Mokhtari A, Parsonage W, Pickering JW, Pemberton CJ, Reich C, Richards AM, Sandoval Y, Than MP, Toprak B, Troughton RW, Worster A, Zeller T, Ziegler A, Blankenberg S; ARTEMIS study group. Personalized diagnosis in suspected myocardial infarction. Clin Res Cardiol. 2023 Sep;112(9):1288-1301. doi: 10.1007/s00392-023-02206-3. Epub 2023 May 2.
PMID: 37131096DERIVED
Biospecimen
Biobank bloodsamples
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ulf Ekelund, Professor
Lund University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
July 31, 2022
First Posted
August 2, 2022
Study Start
February 1, 2013
Primary Completion
April 30, 2014
Study Completion
April 30, 2014
Last Updated
November 18, 2023
Record last verified: 2022-09