NCT05482022

Brief Summary

Speaking valve seems to have a beneficial influence on breathing and secretion management in certain patients with tracheostomy. The investigators plan to use a speaking valve during respiratory physical therapy sessions in participants with disturbances of consciousness, who have a tracheostomy, with no need of a mechanical ventilation.

Trial Health

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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Aug 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 25, 2022

Completed
7 days until next milestone

First Posted

Study publicly available on registry

August 1, 2022

Completed
Same day until next milestone

Study Start

First participant enrolled

August 1, 2022

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 27, 2025

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 15, 2026

Completed
Last Updated

August 14, 2025

Status Verified

August 1, 2025

Enrollment Period

2.7 years

First QC Date

July 25, 2022

Last Update Submit

August 10, 2025

Conditions

Outcome Measures

Primary Outcomes (2)

  • change from baseline oxygen saturation

    at physical therapy sessions

    15 minutes

  • change from baseline breathing rate

    at physical therapy sessions

    15 minutes

Secondary Outcomes (4)

  • rate of swallowing

    15 minutes

  • percentage of participants presenting vocalization

    2 weeks

  • cough rate

    2 weeks

  • percentage of patients weaned from tracheostomy

    through study completion, an average of 6 months.

Other Outcomes (2)

  • number of desaturation events

    2 weeks

  • number of respiratory physical therapy sessions

    2 weeks

Study Arms (2)

speaking valve

EXPERIMENTAL

Respiratory physical therapy treatments conducted using a speaking valve for 2 weeks (at least 8 treatments).

Device: Shiley™ phonate speaking valve

control

OTHER

Respiratory physical therapy treatments conducted without using a speaking valve .

Other: control

Interventions

The device connects to the tracheostomy tube. Usually used to aid vocalization.

Also known as: speaking valve
speaking valve
controlOTHER

no intervention

control

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • brain injury (traumatic/non-traumatic).
  • tracheostomy.
  • unresponsive wakefulness syndrome or minimally conscious state.
  • fiber optic examination as follows: good mobilization of the vocal cords. No airway granulation, MarianJoy scale score: 1-3.
  • the legal guardian speaks Hebrew.

You may not qualify if:

  • airway stenosis / inflammation.
  • oxygen saturation \<90%.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Loewenstein Rehabilitation Hospital

Raanana, Israel

RECRUITING

Central Study Contacts

Elena Aidinoff, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Head of Intensive Care for Consciousness Rehabilitation Department

Study Record Dates

First Submitted

July 25, 2022

First Posted

August 1, 2022

Study Start

August 1, 2022

Primary Completion

March 27, 2025

Study Completion

January 15, 2026

Last Updated

August 14, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will not share

Locations