The Extension of HAPO Follow-up Study

NCT05477511 | Unknown

• 1 other identifier: HAPO-005
• Study Type: observational
• Target: 900
• Locations: 1 country
• Sites: 1

Brief Summary

The prevalence of diabetes mellitus (DM) and cardiovascular disease (CVD) escalate remarkably worldwide and obesity becomes an epidemic disease. This study is interested in how the model of Developmental Origin of Health and Disease (DOHaD) influence individual's health status as they reach young adulthood. Since the mothers from HAPO study have not been subjected to antenatal treatment on the various degree of maternal hyperglycaemia in pregnancy, this would be an unique cohort that allows determination of the effect of various degree of maternal hyperglycaemia below the level of overt DM, on children's cardiometabolic risk in Chinese population.

Conditions

Hyperglycemia; Pregnancy; Overnutrition; Maternal Obesity During Childbirth; Diabetes Mellitus; Cardiovascular Diseases; Gestational Diabetes Mellitus in Pregnancy; Hypertension

Keywords

Hyperglycemia; Pregnancy; Overnutrition; Maternal Obesity; Diabetes Mellitus; Cardiovascular Diseases; Gestational Diabetes Mellitus; Hypertension; Young Adulthood

Outcome Measures

Primary Outcomes (1)

• Rate of DM in the young adult offspring

  Study specimens would be collected to identify the rate of DM in young adult offspring.

  At a time around 18 years of age

Secondary Outcomes (1)

• Rate of impaired glucose regulation, obesity and adiposity, hypertension and various insulin indices

  At a time around 18 years of age

Study Arms (2)

Mother

Chinese mother in Hong Kong who had been assessed in HAPO follow-up study when their children was at either 7 or 11-14 years of age

18 years old child of the enrolled mother

Children who had been assessed in HAPO follow-up study at either 7 or 11-14 years of age

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hong Kong women and their 18 year-old offspring

You may qualify if:

• Mother-child pairs who had been assessed in HAPO follow-up study at either 7 years or 11-14 years old

You may not qualify if:

• Children born preterm before 37 weeks of gestation
• Non-Chinese
• Mothers' OGTT results were unblinded during pregnancy

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Prince of Wales Hospital

Hong Kong, Hong Kong, China, Shatin, Hong Kong

RECRUITING

Related Publications (1)

• See protocol

  BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Fasting blood, OGTT blood

MeSH Terms

Conditions

Hyperglycemia; Overnutrition; Diabetes Mellitus; Cardiovascular Diseases; Hypertension; Pregnancy in Obesity; Diabetes, Gestational

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Nutrition Disorders; Endocrine System Diseases; Vascular Diseases; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Obesity; Overweight; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Chi Chiu Wang

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Chi Chiu Wang

CONTACT

+852 35052804; ccwang@cuhk.edu.hk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 21, 2022
• First Posted: July 28, 2022
• Study Start: August 28, 2020
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: September 22, 2023

Record last verified: 2023-09

Locations

HK (1)