Patients With Asymptomatic Hyperuricemia Have Stronger Local Inflammatory Response and Worse Outcome After Total Knee Arthroplasty

NCT05476367 | Unknown

• 1 other identifier: 2021-0785
• Study Type: observational
• Target: 614
• Locations: 0 countries
• Sites: N/A

Brief Summary

We identify all patients who had undergone primary total knee arthroplsty(TKA) from April 1, 2015, to March 30, 2016. Patients are grouped by uric acid level. The knee society score(KSS score) and the hospital for special surgery knee score (HSS score) before the surgery and 6 years after the surgery will be collected. Also the clinical data will be collected.

Conditions

Arthritis Knee

Outcome Measures

Primary Outcomes (4)

• CRP

  C-reactive protein

  within 7 days after surgery

• temperature

  The nurses measured the body temperature by Non-contact Ear Thermometer. The temperatures were measured at 6 am, 14 pm, and 18 pm every day, and the patients were kept admitted till day 5. The highest one was chosen for analysis.

  within 7 days after surgery

• HSS score

  the hospital for special surgery knee score

  6 years after surgery

• KSS scores

  knee society score

  6 years after surgery

Study Arms (2)

patients with normal uric acid level

The uric acid level is below 420 μmol/L in men and 360 μmol/L in women

patients with high uric acid level

The uric acid level is higher than 420 μmol/L in men and 360 μmol/L in women.

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients received primary TKA(totla knee arthroplasty) in our hospital.

You may qualify if:

• patients who had undergone primary TKA from April 1, 2015, to March 30, 2016

You may not qualify if:

• (1) infection, (2) rheumatoid arthritis, (3) ankylosing spondylitis, (4) revision surgery, (5) patients with unicondylar knee replacement, (6) patients who have been diagnosed with gout or previous gouty symptoms, and (7) patients combined with preoperative redness or swelling.

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

Related Publications (1)

• Yu J, Mi T, Shao Z, Yan X. The Outcomes of Patients With Hyperuricemia After Total Knee Arthroplasty: A Retrospective Cohort Study. Orthop Surg. 2025 Dec;17(12):3477-3487. doi: 10.1111/os.70197. Epub 2025 Nov 6.

  PMID: 41198532 DERIVED

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 25, 2022
• First Posted: July 27, 2022
• Study Start: August 1, 2022
• Primary Completion: September 1, 2022
• Study Completion: September 1, 2022
• Last Updated: July 27, 2022

Record last verified: 2022-07