Optimizing Cognition Via Exercise and Nutrition

NCT05472831 | Completed DMC

• 1 other identifier: 5P30AG022849-18
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

Investigators propose to test the preliminary efficacy of the refined BAILAMOS™ Latin dance program plus a culturally tailored MIND diet (Mediterranean-DASH diet intervention for neurodegenerative delay) program on cognitive function among older Latinos (ages 50+) at risk of cognitive decline. This project will test whether participants randomized to the BAILAMOS™ Latin dance plus MIND diet experience better cognitive outcomes than participants randomized to the BAILAMOS™ Latin dance plus a health education program.

Conditions

Cognitive Function 1, Social

Keywords

Physical activity; Diet; Health disparities

Outcome Measures

Primary Outcomes (6)

• Montreal Cognitive Assessment (MoCA)

  MoCA version 8.1 Blind will be used to assess global cognition. The MoCA-BLIND assesses different cognitive domains such as attention and concentration, memory, language, conceptual thinking, calculations, and orientation. It contains the same items as the original MoCA except those requiring visual abilities have been removed as this is administered over the phone. Time to administer the MoCA- BLIND is approximately 5-10 minutes. The total possible score is 22 points; a score of 19 or above is considered normal.

  Change in scores from baseline to post-intervention 6 months

• WMS-R: Wechsler Memory Scale-Logical Memory I & II

  Logical Memory I \& II will be used to assess episodic memory. A brief story will be read to the participant who will then asked to retell it immediately (I) and after a 10- min delay filled with other activities (II). The score is the number of the 25 story units recalled immediately (I) and after the delay (II).

  Change in score from baseline to post-intervention 6 months

• Stroop Neuropsychological Screening Test (Trennerry et al., 1989)

  Stroop Test will be used to assess executive function. In Stroop C, participants are shown a list of colors printed in conflicting color ink and are asked to read words (names of colors). The second part of this task is Stroop CW in which participants are shown a list of colors printed in conflicting color ink and are asked to say the color of the ink the word is printed. The scores are the number of words named correctly in 30 seconds and the number of colors named correctly in 30 seconds subtracting the number of errors. respectively.

  Change in score from baseline to post-intervention 6 months

• Digit Span Test (Wechsler, 1987)

  Digit Span Forward \& Backward will be used to assess working memory. Digit strings of increasing length will be read, and the participant is asked to repeat each string forward (Digit Span Forward) or backward (Digit Span Backward). The score is the number of correctly retrieved strings in each part.

  Change in score from baseline to post-intervention 6 months

• Word fluency Test (Welsh et al., 1994)

  Word Fluency will be used to assess executive function. The Word Fluency Test asks participants to name as many animals (part 1) or fruits and vegetables (part 2) as possible in 60 seconds. The score is the sum of the number of animals and the number of fruits and vegetables named.

  Change in score from baseline to post-intervention 6 months

• Digit Ordering Test (Cooper at al., 1991)

  Digit ordering test will be used to assess working memory. For Digit Ordering, digit strings of increasing length will be read and the participant is asked to reorder the digits and say them in ascending order. The score is the number of correctly reordered strings.

  Change in score from baseline to post-intervention 6 months

Secondary Outcomes (8)

• Minutes per day of light and moderate-to-vigorous physical activity via GT3x Actigraph Accelerometer

  Change in minutes per day of light and moderate-to-vigorous physical activity from baseline to post-intervention 6 months

• Godin-Shephard leisure-time physical activity questionnaire (GLTEQ)

  Change in activity score from baseline to post-intervention 6 months

• MIND diet adherence

  Change in MIND diet adherence from baseline to post-intervention 6 months

• National Institutes of Health (NIH) Toolbox: Perceived Stress Fixed Form Age 18+ v2.0

  Change in scores from baseline to post-intervention 6 months

• National Institutes of Health (NIH) Toolbox General Life Satisfaction Fixed Form A Age 18+ v2.0

  Change in scores from baseline to post-intervention 6 months

Study Arms (2)

BAILAMOS dance program plus MIND diet

EXPERIMENTAL

BAILAMOS dance program plus MIND diet: Includes a 6-month, twice a week x 60 minutes/session, virtually delivered Latin dance program plus a 60 minute MIND diet session per week.

Behavioral: BAILAMOS dance program plus MIND diet

BAILAMOS dance program plus Health Education

EXPERIMENTAL

BAILAMOS dance program plus Health Education: Includes a 6-month, twice a week x 60 minutes/session, virtually delivered Latin dance program plus a 60 minute health education session per week.

Behavioral: BAILAMOS dance program plus Health Education

Interventions

BAILAMOS dance program plus MIND diet BEHAVIORAL

The refined BAILAMOS program is a Latin dance, Spanish-language intervention that encompasses six dance styles (Merengue, Cha Cha Cha, Bachata, Salsa, Cumbia and Samba). The program meets twice weekly for 60 minutes per session during 6-months via Zoom. The experimental group will also receive one, 60 minute MIND diet session per week.

BAILAMOS dance program plus MIND diet

BAILAMOS dance program plus Health Education BEHAVIORAL

The refined BAILAMOS program is a Latin dance, Spanish-language intervention that encompasses six dance styles (Merengue, Cha Cha Cha, Bachata, Salsa, Cumbia and Samba). The program meets twice weekly for 60 minutes per session during 6-months via Zoom. The experimental group will also receive one, 60 minute Health Education session per week.

BAILAMOS dance program plus Health Education

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• age 50 years and older
• self-identification as Latino/Hispanic
• ability to understand Spanish
• score of \>21 on the Telephone Interview of Cognitive Status (TICs-m)
• \<3 days or \<90 minutes of moderate-to-vigorous physical activity per week
• self-report having a cardiovascular disease (CVD) OR at least one CVD risk factor (i.e., hypertension, hyperlipidemia, diabetes, obesity, current smoker, or family history of CVD) OR family history of Alzheimer's disease
• administer EASY questionnaire-yes to any question means they will need medical clearance)
• Suboptimal diet assessment \<8
• must be able to attend a one-hour orientation before the start of the intervention
• have access to a tablet or computer with internet access.

You may not qualify if:

• significant physical illness or medical condition that would preclude participation in a dance program
• current or past history of a significant psychiatric condition that would interfere with participation in the study
• presence of self-reported uncontrolled cardiovascular disease or uncontrolled diabetes mellitus
• severe chronic obstructive pulmonary disease
• recent healing or unhealed fracture(s)
• had recurrent falls in the past 12 months
• hip or knee replacement
• participated in a structured dance program for 2 or more days in the past month
• Sub-optimal diet assessment \>8
• Cannot attend a one-hour orientation before the start of the intervention
• Travel for more than 2-weeks throughout course of intervention and do not have access to internet

Sponsors & Collaborators

• University of Illinois at Urbana-Champaign: lead
• University of Illinois at Chicago: collaborator
• National Institute on Aging (NIA): collaborator

Study Sites (1)

University of Illinois at Urbana-Champaign

Urbana, Illinois, 61801, United States

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Susan Hughes, PhD

  University of Illinois at Chicago

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 17, 2021
• First Posted: July 25, 2022
• Study Start: August 15, 2022
• Primary Completion: October 19, 2024
• Study Completion: October 19, 2024
• Last Updated: August 19, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)