Social Cognition Assessment in Young Adults

NCT02922400 | Completed

• 1 other identifier: STU 042011-021
• Study Type: interventional
• Target: 153
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of this study is to determine the efficacy and feasibility of a battery of neuropsychological measures evaluating social cognition and behavior in young adults diagnosed with schizophrenia, autism spectrum disorders, or traumatic brain injury (TBI). It also investigates functional differences in regions of the brain associated with social cognition and differences in cognitive processing. Additionally, this study implements a virtual reality intervention to strengthen social cognition skills.

Conditions

Cognitive Function 1, Social

Keywords

Autism; Traumatic Brain Injury; Schizophrenia; Virtual-Reality Social Cognition Training

Outcome Measures

Primary Outcomes (1)

• Brain Activation Change: Social Cognitive Network

  To examine activation change in the brain as a result of treatment on fMRI measures to further understand the mechanism and predictors of change in young adults with social impairment.

  Change from Pre-training (prior to treatment) to Post-training (immediately following training)

Secondary Outcomes (4)

• Change in Neuropsychological Scores: Recognizing Emotion

  Change from Pre-training (prior to treatment) to Post-training (immediately following training)

• Change in Neuropsychological Scores: Theory of Mind

  Change from Pre-training (prior to treatment) to Post-training (immediately following training)

• Change in Neuropsychological Scores: Social Behavior

  Change from Pre-training (prior to treatment) to Post-training (immediately following training)

• Change in Neuropsychological Scores: Social Functioning

  Change from Pre-training (prior to treatment), to Post-training (immediately following training), and 3-Month follow-up (3 months following completion of training)

Study Arms (1)

Social Cognition Assessment and Training

EXPERIMENTAL

Assessment and training program to enhance social function

Behavioral: Social Cognition Assessment and Training

Interventions

Social Cognition Assessment and Training BEHAVIORAL

The study includes an assessment and treatment phase: The assessment phase will test the efficacy and feasibility of a battery of measures evaluating social cognition and behavior. Functional magnetic resonance imaging (fMRI) will also be used to investigate functional differences in regions of the brain associated with social cognition and differences in cognitive progressing. The treatment phase will assess the efficacy and feasibility of a strategy-based social skills treatment using a virtual reality platform.

Also known as: Virtual Reality Social Cognition Training

Social Cognition Assessment and Training

Eligibility Criteria

• Age: 17 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Current primary diagnosis of schizophrenia, schizoaffective disorder, or autism spectrum disorders as defined by the Diagnostic and Statistical Manual of Mental Disorders, Traumatic Brain Injury (TBI), or healthy control.
• Between the ages of 17 and 40
• TBI must be a close-head injury, at least one year post-injury
• Intelligence Quotient (IQ) at least 80 or above
• Mean Length of Utterance (MLU) must be 4-5 words.

You may not qualify if:

• Not fluent in written and oral English
• Clinical status that requires inpatient or day hospital treatment
• Diagnosed with substance dependence within the last three months
• Inability to read self-report instruments
• History of seizures
• Current primary diagnosis of Bipolar Disorder I or II

Sponsors & Collaborators

• The University of Texas at Dallas: lead
• University of Texas Southwestern Medical Center: collaborator
• Yale University: collaborator

Study Sites (1)

Center for BrainHealth University of Texas at Dallas

Dallas, Texas, 75235, United States

Location

Related Publications (4)

• Kandalaft MR, Didehbani N, Krawczyk DC, Allen TT, Chapman SB. Virtual reality social cognition training for young adults with high-functioning autism. J Autism Dev Disord. 2013 Jan;43(1):34-44. doi: 10.1007/s10803-012-1544-6.

  PMID: 22570145 RESULT

• Didehbani N, Shad MU, Kandalaft MR, Allen TT, Tamminga CA, Krawczyk DC, Chapman SB. Brief report: Insight into illness and social attributional style in Asperger's syndrome. J Autism Dev Disord. 2012 Dec;42(12):2754-60. doi: 10.1007/s10803-012-1532-x.

  PMID: 22527705 RESULT

• Didehbani N, Shad MU, Tamminga CA, Kandalaft MR, Allen TT, Chapman SB, Krawczyk DC. Insight and empathy in schizophrenia. Schizophr Res. 2012 Dec;142(1-3):246-7. doi: 10.1016/j.schres.2012.09.010. Epub 2012 Oct 6. No abstract available.

  PMID: 23043874 RESULT

• Krawczyk DC, Kandalaft MR, Didehbani N, Allen TT, McClelland MM, Tamminga CA, Chapman SB. An investigation of reasoning by analogy in schizophrenia and autism spectrum disorder. Front Hum Neurosci. 2014 Aug 20;8:517. doi: 10.3389/fnhum.2014.00517. eCollection 2014.

  PMID: 25191240 RESULT

MeSH Terms

Conditions

Autistic Disorder; Brain Injuries, Traumatic; Schizophrenia

Condition Hierarchy (Ancestors)

Autism Spectrum Disorder; Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders; Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Schizophrenia Spectrum and Other Psychotic Disorders

Study Officials

• Sandra B Chapman, Ph.D.

  Center for BrainHealth, UT Dallas

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 29, 2016
• First Posted: October 4, 2016
• Study Start: November 1, 2006
• Primary Completion: September 1, 2016
• Study Completion: January 1, 2018
• Last Updated: May 8, 2018

Record last verified: 2018-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)