Impact of Olfactory Odour StimulatioN on Energy EXpenditure
SNEEX
SNEEX - Impact of Olfactory Odour StimulatioN on Energy EXpenditure
1 other identifier
interventional
58
1 country
1
Brief Summary
In this preliminary short-term study it is investigated, whether a short olfactory stimulation with distinct odours impacts energy expenditure in patients with obesity and lean patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable obesity
Started Jan 2022
Typical duration for not_applicable obesity
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 18, 2022
CompletedFirst Submitted
Initial submission to the registry
July 21, 2022
CompletedFirst Posted
Study publicly available on registry
July 25, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
October 30, 2024
CompletedDecember 20, 2023
December 1, 2023
2.4 years
July 21, 2022
December 13, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Change in Energy Expenditure
change in energy expenditure as assessed via calorimetry after olfactory stimulation with different odours.
6 hours
Secondary Outcomes (5)
Energy Expenditure, Additional Odours
6 hours
Heart Rate
6 hours
Blood Pressure
6 hours
Metabolic Parameters
6 hours
Glucose Levels
6 hours
Study Arms (2)
Obese
OTHERAge 18-55 years Obesity (BMI ≥30 kg/m2) Written informed consent Normosmia (defined by sniffing Sticks test)
Lean
OTHERAge 18-55 years Lean (BMI 18-25 kg/m2) Written informed consent Normosmia (defined by sniffing Sticks test)
Interventions
Participants are exposed to different odours and energy expenditure is assessed via indirect calorimetry.
Eligibility Criteria
You may qualify if:
- Age 18-55 years
- Obesity (BMI ≥30 kg/m2) and Lean (BMI 18-25 kg/m2)
- Written informed consent
- Normosmia (defined by sniffing Sticks test)
You may not qualify if:
- Chronic or acute sinusitis
- Surgical intervention of the nasal cavity or the paranasal sinus
- Known allergy to odors used in the study
- Smokers
- Current illicit drug abuse including daily marijuana and cannabidiol (CBD) consumption (alcohol ≤2 drinks per day allowed)
- Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease)
- Diabetes mellitus
- Treatment with insulin sensitizing drugs including Glucagon-like Peptide (GLP)-1 analogues within the last 3 months
- History of neurodegenerative diseases, severe head trauma
- Severe renal impairment (e.g. estimated glomerular filtration rate \<30 ml/min/m2)
- Known liver cirrhosis or other severe liver impairment
- Use of any kind of decongestant more than twice a week
- Use of cortisone-containing nasal spray within the last 3 months
- Acute upper respiratory tract infection
- Uncontrolled dysthyroidism
- +8 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital Basel
Basel, Switzerland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- OTHER
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator, Prof. Dr. med.
Study Record Dates
First Submitted
July 21, 2022
First Posted
July 25, 2022
Study Start
January 18, 2022
Primary Completion
June 30, 2024
Study Completion
October 30, 2024
Last Updated
December 20, 2023
Record last verified: 2023-12