Beetroot Juice Resistance Training Older Adults

NCT05460351 | Completed

• 1 other identifier: IRB00025941
• Study Type: interventional
• Target: 24
• Locations: 0 countries
• Sites: N/A

Brief Summary

The present study compared the effects of a nitrate containing beetroot juice supplement (BRJ+Nitrate) vs. a placebo (Control) on total and regional fat free mass, quadriceps muscle strength, lower body mobility, and VO2peak in healthy, older adults undergoing a 10-week long progressive resistance training program with protein supplementation.

Conditions

Sarcopenia; Old Age; Atrophy

Outcome Measures

Primary Outcomes (19)

• Whole body fat free mass

  Mass of fat free tissue

  Collected at baseline

• Whole body fat mass

  Mass of fat tissue

  Collected at baseline

• Thigh muscle

  Volume of thigh muscle

  Collected at baseline

• Thigh intermuscular fat

  Volume of fat in the thigh muscle

  Collected at baseline

• Thigh subcutaneous fat

  Volume of subcutaneous fat in the thigh

  Collected at baseline

• Visceral fat

  Volume of visceral fat

  Collected at baseline

• Muscle strength

  Strength of quadriceps muscle at a speed of 60 degrees per second

  Collected at baseline

• 400 meter walk

  Time to walk 400 meters

  Collected at baseline

• Stair climb time

  Time to ascend and descend 12 stairs

  Collected at baseline

• Peak oxygen consumption

  Peak oxygen consumed at maximal exercise during graded exercise testing

  Collected at baseline

• Whole body fat free mass

  mass of fat free tissue

  Collected at 10-weeks

• Whole body fat mass

  Mass of fat tissue

  Collected at 10-weeks

• Thigh muscle

  Volume of thigh muscle

  Collected at 10-weeks

• Thigh intermuscular fat

  Volume of fat in the thigh muscle

  Collected at 10-weeks

• Thigh subcutaneous fat

  Volume of subcutaneous fat in the thigh

  Collected at 10-weeks

• Visceral fat

  Volume of visceral fat

  Collected at 10-weeks

• Muscle strength

  Strength of quadriceps muscle at a speed of 60 degrees per second

  Collected at 10-weeks

• 400 meter walk

  Time to walk 400 meters

  Collected at 10-weeks

• Stair climb time

  Time to ascend and descend 12 stairs

  Collected at 10-weeks

Study Arms (2)

BRJ+Nitrate

EXPERIMENTAL

This arm underwent a 3 days a week, 10 weeks of resistance exercise training program and consumed for a 70 mL bottle of beetroot juice containing 380 mg of nitrate plus a 15 dose of whey protein after each exercise session.

Dietary Supplement: BRJ+Nitrate

Control

PLACEBO COMPARATOR

This arm underwent a 3 days a week, 10 weeks of resistance exercise training program and consumed for a 70 mL bottle of beetroot juice containing 0 mg of nitrate plus a 15 dose of whey protein after each exercise session.

Dietary Supplement: Control

Interventions

BRJ+Nitrate DIETARY_SUPPLEMENT

Participants in this group drank a 70 mL bottle of Beet It Sport drink with nitrate plus 15 grams of whey protein 3 days a week following a resistance exercise training program

BRJ+Nitrate

Control DIETARY_SUPPLEMENT

Participants in this group drank a 70 mL bottle of Beet It Sport drink without nitrate plus 15 grams of whey protein 3 days a week following a resistance exercise training program

Control

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Able to provide own transportation to study testing visits and intervention
• Able to read and write in English
• Nondiabetic, i.e. fasting glucose \< 126 mg/dl
• Sedentary (less than 60 minutes of moderate intensity structured physical activity each week and occurs in no more than 10 minute blocks and not participating in a resistance exercise training program)
• Willingness to provide informed consent and participate in intervention. Participants with diagnosed depression were permitted to participate provided that they have been medically stable without medication change for at least 3 months.

You may not qualify if:

• Smoking or use of chewing tobacco
• Involved in another intervention research study
• Diabetic (type 1 or 2)
• Atrophic gastritis
• Hypo- or hyperthyroidism
• Gout or history of kidney stones
• History of hypotension
• Premenopausal (women)
• Aversion to study-related testing procedures
• Allergy/sensitivity/aversion to beetroot beverages or protein supplement
• Medical conditions with contraindications for engaging in resistance training program or taking the protein supplement
• Systemic, uncontrolled diseases (diabetes, recent (last 6 months) or current treatment of cancer, thyroid disorders, cardiovascular disease, COPD, or inflammatory bowel diseases)
• Use of any of the following medications: phosphodiesterase type 5 inhibitors, nitroglycerin or nitrate preparations, proton pump inhibitors, or medications for hypothyroidism
• Potential inability to complete the tasks required for the protocol as well as conditions that may interfere with interpretation of results including: inability to ambulate, severe congestive heart failure or severe cardiovascular disease, neoplasm for practical and neurophysiologic reasons
• Individuals with contraindications for performing a graded exercise test or have medical contraindications for participating in a scheduled exercise training program

Sponsors & Collaborators

• Wake Forest University: lead

MeSH Terms

Conditions

Sarcopenia; Atrophy

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: A third party not involved with the conduct of the study provided research staff with the beetroot juice in participant specific coded bottles. The research staff then distributed these coded bottles to the participant. At the end of the trial, the code was revealed for intervention assignment.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Participants will be randomized into one of two groups. The first group will consume daily beetroot juice containing 380 mg of nitrate and the second group will consume daily beetroot juice with nitrate removed. Both groups will undergo resistance exercise training and consume a protein supplement

Study Record Dates

• First Submitted: July 4, 2022
• First Posted: July 15, 2022
• Study Start: February 1, 2014
• Primary Completion: December 1, 2014
• Study Completion: May 1, 2015
• Last Updated: July 15, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share