Effect of Dietary Protein Intake Distribution on Protein Metabolism and Skeletal Muscle

NCT02787889 | Completed

• 1 other identifier: 139057
• Study Type: interventional
• Target: 19
• Locations: 0 countries
• Sites: N/A

Brief Summary

The investigators determined effects of 8-week dietary protein intake in mixed meals with uneven or even consumption pattern on the metabolic outcomes of whole-body net protein synthesis and muscle protein synthesis in older participants.

Conditions

Sarcopenia

Outcome Measures

Primary Outcomes (1)

• Changes in net protein synthesis rate

  Change from Baseline to 8 weeks

Study Arms (2)

Uneven Protein Intake Pattern

EXPERIMENTAL

Subjects consumed either dietary protein intake at 1.1g protein/kg/day over 8 weeks.Each participant will consume 15%/2-%/65% of total protein in breakfast, lunch, and dinner, respectively)\] on net protein synthesis over 8 weeks.

Other: Uneven Protein intake pattern

Even Protein Intake Pattern

EXPERIMENTAL

Subjects consumed either dietary protein intake at 1.1g protein/kg/day over 8 weeks. Each participant will consume 33% of total protein consumed each meal

Other: Even Protein Intake Pattern

Interventions

Uneven Protein intake pattern OTHER

Each participant will consume 15%/2-%/65% of total protein in breakfast, lunch, and dinner, respectively)\] on net protein synthesis over 8 weeks.

Uneven Protein Intake Pattern

Even Protein Intake Pattern OTHER

Each participant will consume 33% of total protein consumed each meal

Even Protein Intake Pattern

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women, ages 50-70 years
• BMI between 24 and 30 kg/m2

You may not qualify if:

• Current diagnosis of diabetes
• History of malignancy in the 6 months prior to enrollment
• History of lactose intolerance or dairy allergy
• History of egg allergy or intolerance
• History of gastrointestinal bypass surgery.
• History of a chronic inflammatory condition or other chronic disease (Lupus, HIV/AIDS, etc)
• Subjects who do not or will not eat animal proteins
• Subjects who cannot refrain from consuming protein or amino acid supplements during their participation in this study
• Subjects who report regular resistance exercise (more than twice per week)
• Hemoglobin less than 9.5 mg/dL at the screening visit
• Platelets less than 150,000 at the screening visit
• Concomitant use of corticosteroids (ingestion, injection or transdermal)
• Any other disease or condition that would place the subject at increased risk of harm if they were to participate, at the discretion of the study physician

Sponsors & Collaborators

• University of Arkansas: lead

Related Publications (1)

• Kim IY, Schutzler S, Schrader AM, Spencer HJ, Azhar G, Wolfe RR, Ferrando AA. Protein intake distribution pattern does not affect anabolic response, lean body mass, muscle strength or function over 8 weeks in older adults: A randomized-controlled trial. Clin Nutr. 2018 Apr;37(2):488-493. doi: 10.1016/j.clnu.2017.02.020. Epub 2017 Mar 3.

  PMID: 28318687 DERIVED

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Arny A Ferrando, Ph.D.

  University of Arkansas

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 12, 2016
• First Posted: June 1, 2016
• Study Start: January 1, 2014
• Primary Completion: May 1, 2015
• Study Completion: May 1, 2015
• Last Updated: June 1, 2016

Record last verified: 2016-05