Analysis of Exhaled Breath From Patients With Lung-/Airway Diseases (BigExBrESs)
BigExBrESs
1 other identifier
observational
5,000
1 country
1
Brief Summary
Ananlyis of exhaled breath of patients with lung-/airway diseases to identify and distinguish respiratory diseases, and improve the disease manangament.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2021
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 11, 2021
CompletedFirst Submitted
Initial submission to the registry
June 30, 2022
CompletedFirst Posted
Study publicly available on registry
July 14, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2026
August 15, 2024
August 1, 2024
5.6 years
June 30, 2022
August 14, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Molecular breath pattern
Comparison of molecular weights of breath features from patients with different respiratory diseases
at baseline
Secondary Outcomes (4)
Change in molecular breath pattern
over one year
Symptoms
at baseline
Inflammatory markers
at baseline
Controls
at baseline
Study Arms (2)
Lung-/Airway diseases
Patients with lung-/airway diseases
Controls
Participants without lung-/airway disease
Interventions
Eligibility Criteria
General population
You may qualify if:
- Signed informed consent
- Age ≥ 18 years at study entry
You may not qualify if:
- Physical or intellectual impairment precluding informed consent or protocol adherence
- Known pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Zurichlead
- Deep Breath Intelligence (DBI)collaborator
Study Sites (1)
University Hospital Zurich
Zurich, Canton of Zurich, 8091, Switzerland
Related Publications (1)
Basler S, Fricke K, Sievi NA, Arvaji A, Schmidt F, Herth J, Baur DM, Kohler M, Ulrich S, Lichtblau M. Exploring breath metabolomics as a non-invasive tool for detecting pulmonary vascular disease. Eur Heart J Open. 2025 May 23;5(3):oeaf060. doi: 10.1093/ehjopen/oeaf060. eCollection 2025 May.
PMID: 40474893DERIVED
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 30, 2022
First Posted
July 14, 2022
Study Start
May 11, 2021
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
December 31, 2026
Last Updated
August 15, 2024
Record last verified: 2024-08