Predictors of Pulmonary Hypertension in Patients With Hypersensitivity Pneumonitis
1 other identifier
interventional
60
1 country
1
Brief Summary
Hypersensitivity pneumonitis (HP) is a complex immune mediated disorders caused by repeated inhalation of and sensitization to wide range of antigens including organic particles and chemical compounds, leading to exaggerated immuneresponse. Hypersenstivity pneumonitis is a common form of diffuse parenchymal lung diseases in Egypt .Pulmonary hypertension has been found as a complication of a number of diseases affecting the lung interstitium, including hypersensitivity pneumonitis, with subsequent affection of the life expectancy Rationale of the study: to find predictors for the development of pulmonary hypertension in patients with hypersensitivity pneumonitis
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Aug 2019
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 31, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
March 15, 2021
CompletedFirst Submitted
Initial submission to the registry
July 4, 2022
CompletedFirst Posted
Study publicly available on registry
July 14, 2022
CompletedJuly 14, 2022
July 1, 2022
1.3 years
July 4, 2022
July 12, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Percentage of pulmonary hypertension in patients with HP
primary oucome
6 months
Study Arms (2)
HP without Pulmonary hypertion
NO INTERVENTIONHRCT chest , pulmonary functions and echocardiography
HP with Pulmonary hypertion
ACTIVE COMPARATORHRCT chest , pulmonary functions ,echocardiography and RT heart catheter in high echocardiographic probability of PH
Interventions
Right heart catheterization was performed for 4 cases with high probability of pulmonary hypertension using multi-lumen swan ganz catheter.
Eligibility Criteria
You may qualify if:
- All patients with confirmed diagnosis of Hypersensitivity pneumonitis
You may not qualify if:
- Other interstitial lung diseases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
Study Sites (1)
Kasr alainy school of medicine
Cairo, 11562, Egypt
Related Publications (1)
Elnady MA, Elkorashy R, Nabil A, Ibrahim EK. Predictors of pulmonary hypertension in patients with hypersensitivity pneumonitis. BMC Pulm Med. 2023 Feb 9;23(1):61. doi: 10.1186/s12890-023-02347-1.
PMID: 36759788DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor of pulmonology
Study Record Dates
First Submitted
July 4, 2022
First Posted
July 14, 2022
Study Start
August 1, 2019
Primary Completion
October 31, 2020
Study Completion
March 15, 2021
Last Updated
July 14, 2022
Record last verified: 2022-07
Data Sharing
- IPD Sharing
- Will not share