NCT05452109

Brief Summary

The blood flow restriction method can have similar or superior effects to high-intensity exercises even in a short duration, which can positively affect some performance parameters, can be applied with low-intensity load and cause hypertrophy in the muscle by providing high metabolic stress, facilitating muscle growth without significantly changing the total training dose. The aim of this study is to investigate whether adding the blood flow restriction method to the classical training program can be more effective than the classical training applied alone in the development of football-related performance parameters.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Dec 2022

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 1, 2022

Completed
1 month until next milestone

First Posted

Study publicly available on registry

July 11, 2022

Completed
5 months until next milestone

Study Start

First participant enrolled

December 12, 2022

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 27, 2023

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 27, 2023

Completed
Last Updated

January 23, 2024

Status Verified

June 1, 2023

Enrollment Period

5 months

First QC Date

June 1, 2022

Last Update Submit

January 20, 2024

Conditions

Vascular OcclusionSoccerExerciseEMG

Outcome Measures

Primary Outcomes (1)

  • Evaluation of Muscle Strength and Endurance

    Isokinetic dynamometer

    6 weeks

Secondary Outcomes (8)

  • Evaluation of Lower Extremity Power

    6 weeks

  • Evaluation of Aerobic Endurance

    6 weeks

  • Evaluation of Change of Direction Speed

    6 weeks

  • Evaluation of Reactive Agility

    6 weeks

  • Evaluation of Dynamic Balance

    6 weeks

  • +3 more secondary outcomes

Study Arms (2)

Blood Flow Restriction + Classical Training

EXPERIMENTAL
Other: Blood Flow Restriction

Classical Training Alone

EXPERIMENTAL
Other: Classical Training Alone

Interventions

Blood Flow RestrictionOTHER

Blood flow restriction with low load (30-50% 1RM) for 2 sessions in a week for 6 weeks during classical training will be applied.

Blood Flow Restriction + Classical Training
Classical Training AloneOTHER

Classical training same as Group 1with moderate to high load (70-90% 1RM) for 2 sessions in a week for 6 weeks will be applied without blood restriction.

Classical Training Alone

Eligibility Criteria

Age18 Years - 30 Years
Sexmale(Gender-based eligibility)
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Being a male between the ages of 18-30 years
  • Volunteer to participate in the study
  • Playing football in one of the clubs in Istanbul for at least 1 year
  • Being in the pre-season of the club
  • Absence of any ongoing musculoskeletal problems that limit exercising

You may not qualify if:

  • Having at least one of the contraindications preventing the application of blood flow restriction (Smoking, previous venous thromboembolism, risk of peripheral vascular disease (ankle-brachial index \<0.9), coronary heart disease, hypertension, hemophilia, etc.).
  • History of sports injury in the last 6 months
  • Orthopedic lower extremity surgery in the last 1 year
  • Body mass index ≥ 30 kg/m2

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Biruni University

Istanbul, Turkey (Türkiye)

Location

Istanbul University Cerrahpasa

Istanbul, Turkey (Türkiye)

Location

Related Publications (1)

  • Kara Kaya B, Alpozgen AZ, Alpozgen MR, Dikmen G. Performance and injury-related effects of low-load blood flow restriction training in amateur soccer players: a randomized controlled trial. BMC Sports Sci Med Rehabil. 2025 Dec 20. doi: 10.1186/s13102-025-01416-8. Online ahead of print.

    PMID: 41422254DERIVED

MeSH Terms

Conditions

Motor Activity

Interventions

Blood Flow Restriction Therapy

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy Modalities

Study Officials

  • Ayse Zengin Alpözgen, PhD

    Istanbul University - Cerrahpasa

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Lecturer

Study Record Dates

First Submitted

June 1, 2022

First Posted

July 11, 2022

Study Start

December 12, 2022

Primary Completion

April 27, 2023

Study Completion

October 27, 2023

Last Updated

January 23, 2024

Record last verified: 2023-06

Data Sharing

IPD Sharing
Will not share

Locations

TU(2)