LSTR
Clinical And Radiographic Evaluation Of Lesion Sterilization And Tissue Repair Versus Zinc Oxide And Eugenol For Treatment of Necrotic Primary Molars
Sponsor study identifier
interventional
60
1 country
1
Study Start
October 1, 2022
Actual (reported)Primary Completion
October 1, 2023
Actual (reported)Study Completion
March 8, 2025
Actual (reported)The aim of this study is to evaluate the clinical and radiographic success of Lesion Sterilization And Tissue Repair \[ LSTR\] antibiotic paste versus Zinc Oxide and Eugenol pulpectomy in the treatment of non-vital primary molars.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 8, 2025
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 29, 2022
Actual (reported)July 8, 2022
Actual (reported)October 1, 2022
Actual (reported)October 1, 2023
Actual (reported)March 8, 2025
Actual (reported)Post oper3tive pain
Measured by verbal question to patient/parents
1 month
Post operative pain
Measured by verbal question to patient/parents
3 months
Post operative pain
Measured by verbal question to patient/parents
6 months
Tenderness
Percussion test using back of a dental mirror
1 month
Tenderness
Percussion test using back of a dental mirror
3 months
Tenderness
Percussion test using back of a dental mirror
6 months
Swelling /sinus tract or fistula
Visual examination
1 month
Swelling /sinus tract or fistula
Visual examination
3 months
Swelling /sinus tract or fistula
Visual examination
6 months
Tooth mobility
Mobility test
1 month
Tooth mobility
Mobility test
3 months
Tooth mobility
Mobility test
6 months
Internal /External root resorption
6 months
Furcation involvement /radiolucency
6 months
Lesion sterilization and tissue repair; preparation of modified triple antibiotic paste tap: the chemotherapeutic agents used are metronidazole tablets 500 mg (flagyl®, sanofi, egypt), ciprofloxacin tablets 500 mg (ciproxcin®,. Epico, egypt,), and doxycycline capsules 100 mg (doxymycin™ dt, el-nile pharmaceuticals, egypt).
zinc oxide and eugenol (prevestdent pro™, egypt).
Pulp therapy for necrotic primary molars
Pulp therapy for necrotic primary molars
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Faculty of oral and dental medicine
Cairo, Egypt
Chen X, Liu X, Zhong J. Clinical and radiographic evaluation of pulpectomy in primary teeth: a 18-months clinical randomized controlled trial. Head Face Med. 2017 Oct 27;13(1):12. doi: 10.1186/s13005-017-0145-1.
Luengo-Fereira J, Ayala-Jimenez S, Carlos-Medrano LE, Toscano-Garcia I, Anaya-Alvarez M. Clinical and Radiographic Evaluation of Formocresol and Chloramphenicol, Tetracycline and Zinc Oxide-Eugenol Antibiotic Paste in Primary Teeth Pulpotomies: 24 month follow up. J Clin Pediatr Dent. 2019;43(1):16-21. doi: 10.17796/1053-4625-43.1.4. Epub 2018 Oct 5.
60 participants (actual enrollment reported by the registry).
First Submitted
June 29, 2022
First Posted
July 8, 2022
Study Start
October 1, 2022
Actual (reported)Contact the study team to confirm eligibility.
Moura J, Lima M, Nogueira N, Castro M, Lima C, Moura M, Moura L. LSTR Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for the Treatment of Primary Molars with Pulp Necrosis: A Randomized Controlled Trial. Pediatr Dent. 2021 Nov 15;43(6):435-442.
Navit S, Jaiswal N, Khan SA, Malhotra S, Sharma A, Mukesh, Jabeen S, Agarwal G. Antimicrobial Efficacy of Contemporary Obturating Materials used in Primary Teeth- An In-vitro Study. J Clin Diagn Res. 2016 Sep;10(9):ZC09-ZC12. doi: 10.7860/JCDR/2016/21883.8426. Epub 2016 Sep 1.
Pramila R, Muthu MS, Deepa G, Farzan JM, Rodrigues SJ. Pulpectomies in primary mandibular molars: a comparison of outcomes using three root filling materials. Int Endod J. 2016 May;49(5):413-21. doi: 10.1111/iej.12478. Epub 2015 Jul 4.
Coll JA, Dhar V, Vargas K, Chen CY, Crystal YO, AlShamali S, Marghalani AA. Use of Non-Vital Pulp Therapies in Primary Teeth. Pediatr Dent. 2020 Sep 15;42(5):337-349.
Zacharczuk GA, Toscano MA, Lopez GE, Ortolani AM. Evaluation of 3Mix-MP and pulpectomies in non-vital primary molars. Acta Odontol Latinoam. 2019 Apr 1;32(1):22-28.
Smail-Faugeron V, Glenny AM, Courson F, Durieux P, Muller-Bolla M, Fron Chabouis H. Pulp treatment for extensive decay in primary teeth. Cochrane Database Syst Rev. 2018 May 31;5(5):CD003220. doi: 10.1002/14651858.CD003220.pub3.
Primary Completion
October 1, 2023
Actual (reported)Study Completion
March 8, 2025
Actual (reported)Last Updated
August 3, 2025
Record last verified: 2025-07
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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