Modulating Speech Perception With Current Stimulation
SPEECHSTIM
3 other identifiers
interventional
126
1 country
1
Brief Summary
This study aims to further develop tACS as a tool to improve speech perception, by manipulation of brain-speech synchronisation ("entrainment"), thereby transforming a promising approach into a technique that can benefit to society on a large scale.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable healthy
Started Jul 2022
Longer than P75 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 1, 2022
CompletedStudy Start
First participant enrolled
July 1, 2022
CompletedFirst Posted
Study publicly available on registry
July 6, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2025
CompletedAugust 19, 2022
August 1, 2022
3.2 years
July 1, 2022
August 18, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
correctly identified words
percentage of correctly identified words during or after tACS who will permit to evaluate efficacy of tACS to modulate speech perception and neural responses in different experimental conditions (involving electrophysiological, brain imaging, and perceptual measures)
Day 1
Secondary Outcomes (3)
correctly identified words with different modality
day 1
oscillatory activities
Day 1
neural activity
Day 1
Study Arms (4)
Experiment 1
EXPERIMENTALThe aim of Experiment 1 is to understand how tACS operates on the neural level
Experiment 2
EXPERIMENTALThe aim of Experiment 2 is to increase efficacy of tACS and, consequently, its potential to play an important role in research and everyday life applications
Experiment 3
EXPERIMENTALThe aim of Experiment 3 is to reveal how tACS can boost speech perception in a multi-speaker scenario.
Experiment 4
EXPERIMENTALThe aim of Experiment 4 is to combine established techniques to create novel opportunities to improve speech perception
Interventions
transcranial alternating current stimulation (tACS) used to manipulate how neural activity aligns to speech rhythm, leading to changes in speech perception
analyse rhythmic electroencephalography responses that outlast the stimulation
Using brain imaging (fMRI) to predict optimal stimulation protocols for individual participants
Using neurofeedback to teach participants to enhance their own neural entrainment
Eligibility Criteria
You may qualify if:
- Subject aged between 18 and 50 years old
- informed written consent
- Absence of pro-epileptogenic drugs
- Absence of visual or hearing impairment incompatible with participation in the study
You may not qualify if:
- Pregnant or breastfeeding women,
- Persons protected by law adults under guardianship or curatorship
- Persons not affiliated to a Social Security scheme
- Subjects with progressive psychiatric or neurological pathology
- Subjects with a contraindication to tCS or MRI (history of epilepsy, severe head injury or brain/spinal cord surgery, cardiac pacemaker/defibrillator, implanted equipment activated by electrical, magnetic or mechanical system, hemostatic clip carriers of intracerebral aneurysms or carotid arteries, orthopedic implant carriers, claustrophobic, pregnancy).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CHU Toulouse
Toulouse, 31059, France
Related Publications (3)
van Bree S, Sohoglu E, Davis MH, Zoefel B. Sustained neural rhythms reveal endogenous oscillations supporting speech perception. PLoS Biol. 2021 Feb 26;19(2):e3001142. doi: 10.1371/journal.pbio.3001142. eCollection 2021 Feb.
PMID: 33635855BACKGROUNDZoefel B, Davis MH, Valente G, Riecke L. How to test for phasic modulation of neural and behavioural responses. Neuroimage. 2019 Nov 15;202:116175. doi: 10.1016/j.neuroimage.2019.116175. Epub 2019 Sep 6.
PMID: 31499178BACKGROUNDZoefel B, Allard I, Anil M, Davis MH. Perception of Rhythmic Speech Is Modulated by Focal Bilateral Transcranial Alternating Current Stimulation. J Cogn Neurosci. 2020 Feb;32(2):226-240. doi: 10.1162/jocn_a_01490. Epub 2019 Oct 29.
PMID: 31659922BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mathieu MARX, PU-PH
University Hospital, Toulouse
Central Study Contacts
Benedikt ZOEFEL, MD
CONTACT
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Masking Details
- masking to the conditions of the experiments
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 1, 2022
First Posted
July 6, 2022
Study Start
July 1, 2022
Primary Completion
September 1, 2025
Study Completion
September 1, 2025
Last Updated
August 19, 2022
Record last verified: 2022-08
Data Sharing
- IPD Sharing
- Will not share