Relationship Between Ectopic Pregnancy and Thyroid Disorders

NCT05446012 | Completed

• 1 other identifier: SiirtU
• Study Type: observational
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

Fallopian tubes participate in the incorporation of gametes and embryos into the endometrial cavity. It also provides an optimal environment for flattening and early embryonic development. Tubal pathologies can cause both primary and secondary infertility. This condition has been associated with overt and subclinical hypothyroidism. However, the effects of hypothyroidism on tubal activity are not fully known. Although a few animal experiment studies on this subject have been published, there is no study on this subject in the literature. Demonstrating that epithelial and smooth muscle cells of rat fallopian tubes express thyroid receptors in animal experiments showed that fallopian tubes are targets for thyroid hormones. Again, in an animal experiment study, it was revealed that thyroid hormones have an important control on glycogen and lipid storage, lipid signaling and lymphocyte infiltration, which have an important role in maintaining the microenvironment in the rat fallopian tubes. This microenvironment is necessary for fertilization, sperm capacitation and gamete development. In another animal experimental study, it was thought that changes in the size of the epithelium of the fallopian tubes and cell metabolism in hypothyroid rabbits may affect oviductal activity and reproductive functions. An ectopic pregnancy is defined as a pregnancy implanted outside of the uterus. Ectopic pregnancy \>98% implants in the fallopian tube. The etiology of ectopic pregnancy is unclear, but tubal implantation is probably due to impaired embryo-tubal transport. This is due to changes in the tubal environment. Based on this information, we aim to determine the possible relationship between hypothyroidism and ectopic pregnancy in humans in our study.

Conditions

Ectopic Pregnancy; Thyroid Diseases; Pregnancy, Ectopic

Keywords

Thyroid disorders; pregnancy; Ectopic

Outcome Measures

Primary Outcomes (1)

• Thyroid dysfunction and ectopic pregnancy

  TSH, T3, T4, TT3, TT4, Thyroglobulin, Anti peroxidase antibody, Anti thyroglobulin antibody,TSH receptors antibody will be measured in patients diagnosed with ectopic pregnancy

  Through study completion, an average of 5 months

Study Arms (2)

women diagnosed with ectopic pregnancy (n: 40)

thyroid function tests (TSH, sT3, sT4, TT3, TT4, thryoglobulin, Anti-Peroxidase Antibody, Anti- thryoglobulin Antibody, TSH receptors antibody levels) will be done in women diagnosed with ectopic pregnancy

Diagnostic Test: thyroid function tests

Control group pregnants (n:40)

thyroid function tests (TSH, sT3, sT4, TT3, TT4, thryoglobulin, Anti-Peroxidase Antibody, Anti- thryoglobulin Antibody, TSH receptors antibody levels) will be done in pregnant women in early pregnancy week.

Diagnostic Test: thyroid function tests

Interventions

thyroid function tests DIAGNOSTIC_TEST

blood sample for thyroid function tests (TSH,T3,T3,Anti peroxidase antibody, anti thyroglobulin antibody)

Control group pregnants (n:40); women diagnosed with ectopic pregnancy (n: 40)

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

women over 18 years of age diagnosed with ectopic pregnancy or early pregnancy

You may qualify if:

• \>18 years of age
• Having an early pregnancy or ectopic pregnancy

You may not qualify if:

• using medications due to thyroid gland dysfunction
• history of ectopic pregnancy
• history of tubal surgery

Sponsors & Collaborators

• Siirt University: lead

Study Sites (1)

Siirt Üniversity Medical Faculty

Siirt, 56000, Turkey (Türkiye)

Location

Related Publications (3)

• Mendez-Tepepa M, Zepeda-Perez D, Espindola-Lozano M, Rodriguez-Castelan J, Arroyo-Helguera O, Pacheco P, Nicolas-Toledo L, Cuevas-Romero E. Hypothyroidism modifies differentially the content of lipids and glycogen, lipid receptors, and intraepithelial lymphocytes among oviductal regions of rabbits. Reprod Biol. 2020 Jun;20(2):247-253. doi: 10.1016/j.repbio.2020.02.004. Epub 2020 Feb 20.

  PMID: 32089504 BACKGROUND

• Oner J, Oner H. Immunodetection of thyroid hormone receptor (alpha1/alpha2) in the rat uterus and oviduct. Acta Histochem Cytochem. 2007 Jul 3;40(3):77-81. doi: 10.1267/ahc.06026.

  PMID: 17653299 BACKGROUND

• Anaya-Hernandez A, Rodriguez-Castelan J, Nicolas L, Martinez-Gomez M, Jimenez-Estrada I, Castelan F, Cuevas E. Hypothyroidism affects differentially the cell size of epithelial cells among oviductal regions of rabbits. Reprod Domest Anim. 2015 Feb;50(1):104-11. doi: 10.1111/rda.12455. Epub 2014 Nov 18.

  PMID: 25405800 BACKGROUND

MeSH Terms

Conditions

Pregnancy, Ectopic; Thyroid Diseases; Choristoma

Interventions

Thyroid Function Tests

Condition Hierarchy (Ancestors)

Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Endocrine System Diseases; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Endocrine; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Şerif Aksin

  Siirt University Medical Faculty Obstetrics and Gynecology Departmant

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: June 26, 2022
• First Posted: July 6, 2022
• Study Start: June 25, 2022
• Primary Completion: December 5, 2022
• Study Completion: December 5, 2022
• Last Updated: December 6, 2022

Record last verified: 2022-12

Locations

TU (1)