"Escape" Phenomenon of the Antihypertensive Therapy Efficacy
ESCAPE
The Role of Ambulatory Blood Pressure Characteristics, Features of the Structural and Functional Vascular Wall State, the Presence and Severity of Obstructive Sleep Apnea Syndrome in Predicting the "Escape" Phenomenon of the Antihypertensive Therapy Efficacy.
1 other identifier
observational
165
1 country
1
Brief Summary
A little attention is paid to the AHT efficacy escaping problem, which can be explained by the AHT correction simplicity and rapid achievement of the target BP level. Nevertheless, modern statistic data on the effective AH treatment described above let us assume that AHT correction is either totally absent or is untimely in case of the "escape" phenomenon development. This could be one of the main reasons for the high prevalence of ineffective AH treatment. The aim of this study is to determine AHT efficacy "escape" phenomenon timeline and its predictors in hypertensive patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Sep 2015
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 29, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2016
CompletedFirst Submitted
Initial submission to the registry
June 22, 2022
CompletedFirst Posted
Study publicly available on registry
June 29, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 30, 2025
CompletedJune 29, 2022
June 1, 2022
1.3 years
June 22, 2022
June 28, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Assessment of BP increasing higher the target level when taking the same therapy
Assessment of attenuation of efficacy of previously adequate antihypertensive therapy by using different BP measurement methods
1-6 months
Secondary Outcomes (1)
Disease course: assessment of major CVE and death occurrence
10 years
Study Arms (1)
"Escape" Phenomenon of the Antihypertensive Therapy Efficacy
Men and women aged 18-90 years with arterial hypertension grade 1-3, stage I-II and initially achieved target BP levels while taking 2-3-component AHT.
Interventions
Assessment of the 24-h blood pressure profile
Assessment of the arterial stiffness
Assessment of the arterial stiffness
Assessment of the sleep breath disturbances
Eligibility Criteria
Men and women aged 18-90 years with arterial hypertension grade 1-3, stage I-II and initially achieved target BP levels while taking 2-3-component AHT.
You may qualify if:
- Arterial hypertension (AH) grade 1-3, stage I-II
- High compliance during the follow-up period (≥ 85%)
- Initially achieved target office BP levels while taking 2-3-component AHT
You may not qualify if:
- Secondary AH
- Resistant AH,
- AH III stage,
- PAP- therapy,
- type 2 diabetes mellitus,
- pregnancy
- history of low adherence to treatment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Oksana Mikhailova
Moscow, Russia
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr., clinical reseacher
Study Record Dates
First Submitted
June 22, 2022
First Posted
June 29, 2022
Study Start
September 29, 2015
Primary Completion
December 30, 2016
Study Completion
December 30, 2025
Last Updated
June 29, 2022
Record last verified: 2022-06
Data Sharing
- IPD Sharing
- Will not share