Physical Exercises Influence on Blood Pressure and Arterial Stiffness

NCT02844413 | Completed Phase 4

• 1 other identifier: CMUJ-2015/67
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

Regular exercise is recommended as an adjuvant treatment in hypertensive subjects by both European and American guidelines. Crucially, however, there are no precise recommendations on the type of physical exercise and how it should be instituted A relatively short period (5 months) of regular aerobic interval training (AIT), significantly decreased blood pressure, pulse wave velocity, and most applanation tonometry indexes in hypertensive subjects also undertaking pharmacological treatment in our study.

Conditions

Arterial Hypertension

Outcome Measures

Primary Outcomes (1)

• Pulse wave velocity augmentation of 1.04 [m/s]

  5 months

Secondary Outcomes (1)

• systolic blood pressure reduction of 3.9 [mmHg] and diastolic blood pressure reduction of 2.7 [mmHg]

  5 months

Study Arms (2)

study group

EXPERIMENTAL

implementation of aerobic interval training

Other: aerobic interval training

control group

NO INTERVENTION

control group

Interventions

aerobic interval training OTHER

In the first group (G1), aerobic interval training (AIT) was undertaken for 5 months (40 professional AIT sessions performed two times per week in 50 minute sessions) and followed a specially developed program. The second control group (G2), did not attend any training sessions but received medical advice on how to maintain physical activity as outlined by JNC hypertension guidelines

Also known as: AIT

study group

Eligibility Criteria

• Age: 51 Years - 59 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• subjects who have had previously undergone at least 2 years of combined antihypertensive therapy and who had well controlled hypertension, i.e. below 140/90 mmHg
• subjects whos pharmacological treatment did not change during the study period

You may not qualify if:

• Secondary hypertension
• Chronic kidney or liver failure
• Grade 3 hypertension as defined by European Society of Hypertension 2013
• Chronic obstructive pulmonary disease
• The need for the use of 3 antihypertensives
• Diabetes or other illness affected carbohydrate metabolism
• Previous myocardial infarction
• Other serious conditions which might shorten survival time
• Previous stroke or transient ichemic attack (TIA)
• Other conditions affecting the locomotor system which would significantly limit the ability to undertake exercise
• Symptomatic heart failure
• Lack of informed consent

Sponsors & Collaborators

• Jagiellonian University: lead

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• Tomasz Kameczura, MD, PhD

  Jagiellonian University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: July 12, 2016
• First Posted: July 26, 2016
• Study Start: December 1, 2015
• Primary Completion: December 1, 2015
• Study Completion: May 1, 2016
• Last Updated: July 26, 2016

Record last verified: 2016-07