NCT05434637

Brief Summary

The purpose of this study is to learn more about a type of tinnitus (ringing in the ears) known as "somatosensory tinnitus." This type of tinnitus is suspected when the tinnitus perception changes following head and/or neck movements. This study is also exploring a possible way to treat somatosensory tinnitus.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
72

participants targeted

Target at P50-P75 for not_applicable

Timeline
17mo left

Started Nov 2023

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress64%
Nov 2023Sep 2027

First Submitted

Initial submission to the registry

June 22, 2022

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 28, 2022

Completed
1.3 years until next milestone

Study Start

First participant enrolled

November 1, 2023

Completed
3.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2027

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2027

Last Updated

September 17, 2025

Status Verified

September 1, 2025

Enrollment Period

3.7 years

First QC Date

June 22, 2022

Last Update Submit

September 11, 2025

Conditions

Keywords

Tinnitus

Outcome Measures

Primary Outcomes (1)

  • Change in TFI Score

    The TFI is a 25-item questionnaire that evaluates treatment responsiveness (i.e., changes in functional effects of tinnitus over time). Total possible score ranges from 0-to-100 (scores \>25 indicate tinnitus is a significant problem).

    Measured at at baseline; 8 and 12 weeks post-randomization

Study Arms (3)

Individualized Physiotherapy

EXPERIMENTAL

Individuals randomized to this group will receive physical therapy, personalized for the participant's specific needs, and include exercises to be performed at home.

Other: Physical Therapy

Sound-based Therapy

ACTIVE COMPARATOR

Individuals randomized to this group will receive sound-based therapy, consistent with an audiology-based standard of care treatment.

Other: Sound-based Therapy

Combination Therapy

EXPERIMENTAL

Individuals randomized to this group will receive both individualized physical therapy and sound-based therapy.

Other: Combination Therapy

Interventions

Individuals randomized to this intervention will receive physical therapy, personalized for the participant's specific needs, and include exercises to be performed at home.

Also known as: Individualized Physiotherapy
Individualized Physiotherapy

Individuals randomized to this intervention will receive sound-based therapy, consistent with an audiology-based standard of care treatment.

Also known as: Audiology Therapy
Sound-based Therapy

Individuals randomized to this intervention will receive both individualized physical therapy and sound-based therapy.

Also known as: Physical Therapy + Audiology Therapy
Combination Therapy

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Constant, chronic tinnitus (6-months in duration)
  • bothersome tinnitus based on TFI score and self-reported loudness
  • able to modulate tinnitus perception with head, neck, and/or jaw maneuvers

You may not qualify if:

  • Middle ear pathology
  • not a candidate for physical therapy
  • injury to the temporomandibular area in past 3 months
  • active pathology in the orofacial region

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

VA Portland Health Care System, Portland, OR

Portland, Oregon, 97207-2964, United States

RECRUITING

MeSH Terms

Conditions

Tinnitus

Interventions

Physical Therapy ModalitiesCombined Modality Therapy

Condition Hierarchy (Ancestors)

Hearing DisordersEar DiseasesOtorhinolaryngologic DiseasesSensation DisordersNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

TherapeuticsRehabilitation

Study Officials

  • Sarah Theodoroff, PhD

    VA Portland Health Care System, Portland, OR

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Sarah Theodoroff, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
FED
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 22, 2022

First Posted

June 28, 2022

Study Start

November 1, 2023

Primary Completion (Estimated)

June 30, 2027

Study Completion (Estimated)

September 30, 2027

Last Updated

September 17, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will not share

Locations