NCT05429892

Brief Summary

The long-term goal of FRESH Delivers is to fill a critical gap in knowledge on the role of a home-based food delivery social intervention in the elimination of tobacco-caused cancer health burdens. The central hypothesis is that smokers who receive real-time video-based motivational counseling and home-based food deliveries will have greater cotinine-verified 7-day point prevalence abstinence than those who receive real-time video-based motivational counseling alone or home food delivery alone. The rationale for this approach is that studies show increased odds of smoking cessation with increasing food security.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
540

participants targeted

Target at P75+ for not_applicable

Timeline
5mo left

Started Aug 2023

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress87%
Aug 2023Sep 2026

First Submitted

Initial submission to the registry

May 23, 2022

Completed
1 month until next milestone

First Posted

Study publicly available on registry

June 23, 2022

Completed
1.1 years until next milestone

Study Start

First participant enrolled

August 9, 2023

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 30, 2026

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2026

Expected
Last Updated

August 7, 2025

Status Verified

August 1, 2025

Enrollment Period

2.6 years

First QC Date

May 23, 2022

Last Update Submit

August 1, 2025

Conditions

Keywords

food securitysmoking cessationsocial changemotivational counselinghome food deliverytobacco biomarkers

Outcome Measures

Primary Outcomes (1)

  • Cotinine verified- 7 day point prevalence abstinence

    The study is powered to examine changes in our primary outcome, cotinine-verified 7-day point prevalence abstinence using survey data and collecting a saliva sample.

    Changes from baseline cigarette prevalence at 6 months

Secondary Outcomes (1)

  • Food security

    Changes from baseline food security at 6 months

Other Outcomes (13)

  • Abuse liability - nicotine dependence

    Changes from baseline nicotine dependence at 6 months

  • Abuse liability - carbon monoxide

    Changes from baseline carbon monoxide at 6 months

  • Abuse liability - cotinine

    Changes from baseline cotinine at 6 months

  • +10 more other outcomes

Study Arms (3)

TRTsocialmot1 arm

EXPERIMENTAL

Smokers will receive real-time video-based motivational counseling and home-based food delivery or grocery store gift card. Participants will receive educational material.

Behavioral: Smoking cessation counseling and food delivery

TRTmot3 arm

ACTIVE COMPARATOR

Smokers will receive real-time video-based motivational counseling only. Participants will receive educational material.

Behavioral: Smoking cessation counseling

TRTsocial2 arm

ACTIVE COMPARATOR

Smokers will receive home-based food delivery only or grocery store gift card. Participants will receive educational material.

Behavioral: Food delivery

Interventions

The community health workers will delivery three 30-minute sessions during intervention months 1 through 6 (1,3,6 months) to provide interpersonal level support for smoking cessation. The community health workers will conduct real-time video motivational counseling to clients. The community health workers will implement the 5As (Ask, Advise, Assess, Assist, Arrange) and support smokers in quitting, if ready, and build confidence toward quitting if they are uncertain about change. Smokers enrolled in the TRTsocialmot1 arm will be provided with food boxes or grocery store gift card at 1,3, and 6 months. Healthy meal preparation instructions will be included and delivery by project staff and will reduce transportation barriers to food access rural counties. Participants will receive educational materials at 1, 3, and 6 months.

Also known as: TRTsocialmot1
TRTsocialmot1 arm

The community health workers will deliver three 30-minute sessions during intervention months 1 through 6 (1,3,6 months) to provide interpersonal level support for smoking cessation. The community health workers will conduct real-time video motivational counseling to clients. The community health workers will implement the 5As (Ask, Advise, Assess, Assist, Arrange) and support smokers in quitting, if ready, and build confidence toward quitting if they are uncertain about change. Participants will receive educational materials at 1, 3, and 6 months.

Also known as: TRTmot3 arm
TRTmot3 arm
Food deliveryBEHAVIORAL

Smokers enrolled in the TRTsocial2 arm will be provided with food boxes or grocery store gift card at 1, 3, and 6 months Healthy meal preparation instructions will be included and delivery by project staff and will reduce transportation barriers to food access rural counties. Participants will receive educational materials.

Also known as: TRTsocial2
TRTsocial2 arm

Eligibility Criteria

Age21 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Currently smoke regularly for at least 1 year with a verified carbon monoxide level of 5 ppm or greater
  • Live in Desha, Phillips, Chicot, or Lee Counties
  • Aged 21 to 75
  • Speak English
  • Interest in quitting
  • Provide written/online informed consent
  • Working phone, home address, and email
  • Willingness to use a study provided tablet/phone service
  • Willingness to report COVID-19 symptoms as appropriate to assure everyone's safety during a personal visit.

You may not qualify if:

  • Persons who do not meet the above criteria.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

RECRUITING

MeSH Terms

Conditions

Tobacco Use CessationTobacco Use DisorderSmoking Cessation

Condition Hierarchy (Ancestors)

Health BehaviorBehaviorSubstance-Related DisordersChemically-Induced DisordersMental Disorders

Study Officials

  • Pebbles Fagan, PhD

    University of Arkansas

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Pebbles Fagan, PhD, MPH

CONTACT

Sandilyn Bullock, MPH

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, CARE PROVIDER
Masking Details
The community health workers who will deliver the intervention will not have access to the randomization information. The participants will also not have access to the information the randomization information.
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: The 3-arm trial (180 smokers per arm) will enroll 540 smokers in Chicot, Desha, Lee, and Phillips and deliver the intervention over 6 months. The study is powered to examine our primary outcome, cotinine-verified 7-day point prevalence abstinence, after 6 months and we will conduct a 12-month follow-up survey. The secondary outcome will be food security. 180 smokers aged 21-75 will be randomized to each condition.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 23, 2022

First Posted

June 23, 2022

Study Start

August 9, 2023

Primary Completion

March 30, 2026

Study Completion (Estimated)

September 30, 2026

Last Updated

August 7, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will share

We will coordinate these efforts with the NIMHD research coordinating center to determine what data will be shared across studies.

Shared Documents
STUDY PROTOCOL
Time Frame
At the end of the study
Access Criteria
Contact the PI for the protocol and obtain instructions on how to access. Persons must complete registration.

Locations