Rebreathing-induced Hypoxia and Glucose Levels

NCT05422430 | Completed

• 1 other identifier: STUDY00001555
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this research project is to determine the effect of repeated maximal voluntary apneas on glucose uptake during an oral glucose tolerance test in healthy individuals, individuals with prediabetes and patients with type 2 diabetes.

Conditions

Hypoxemia

Outcome Measures

Primary Outcomes (1)

• Change in plasma glucose levels

  Plasma glucose levels obtained from a venous catheter during a 2-hour oral glucose tolerance test

  Collected at min 0, 30, 60, 90 and 120 minutes of the oral glucose tolerance test

Study Arms (2)

Spontaneous breathing

SHAM COMPARATOR

Participants will be spontaneously breathing during an oral glucose tolerance test.

Behavioral: Spontaneous breathing

Rebreathing-induced hypoxia

EXPERIMENTAL

Participants will rebreathe room air from a low-volume closed-circuit system for a period of 2 minutes.

Behavioral: Rebreathing-induced hypoxia

Interventions

Rebreathing-induced hypoxia BEHAVIORAL

Participants will rebreathe room air from a low-volume closed-circuit system for a period of 2 minutes.

Rebreathing-induced hypoxia

Spontaneous breathing BEHAVIORAL

Participants will be spontaneously breathing during an oral glucose tolerance test.

Spontaneous breathing

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women aged 18 to 80 years old

You may not qualify if:

• Have uncontrolled stage 2 hypertension (˃140/90 mmHg)
• Are smokers
• Are pregnant
• Have a history of cardiovascular disease or indication of cardiovascular disease such as myocardial infarction, left ventricular hypertrophy, ischemic heart disease (or prior ischemia), stroke, and/or other vascular disease
• Have a history of lung disease
• Are taking insulin or more than one antihypertensive medication
• Have poorly controlled diabetes: HbA1c levels ˃ 9%
• Have been previously diagnosed with diabetic complications (nephropathy, neuropathy, retinopathy) by their family doctor

Sponsors & Collaborators

• University of Texas at Austin: lead

Study Sites (1)

The Unviersity of Texas at Austin

Austin, Texas, 78712, United States

Location

Related Publications (10)

• Boyle JP, Thompson TJ, Gregg EW, Barker LE, Williamson DF. Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Popul Health Metr. 2010 Oct 22;8:29. doi: 10.1186/1478-7954-8-29.

  PMID: 20969750 BACKGROUND

• Resnick HE, Foster GL, Bardsley J, Ratner RE. Achievement of American Diabetes Association clinical practice recommendations among U.S. adults with diabetes, 1999-2002: the National Health and Nutrition Examination Survey. Diabetes Care. 2006 Mar;29(3):531-7. doi: 10.2337/diacare.29.03.06.dc05-1254.

  PMID: 16505501 BACKGROUND

• Azevedo JL Jr, Carey JO, Pories WJ, Morris PG, Dohm GL. Hypoxia stimulates glucose transport in insulin-resistant human skeletal muscle. Diabetes. 1995 Jun;44(6):695-8. doi: 10.2337/diab.44.6.695.

  PMID: 7789635 BACKGROUND

• Cartee GD, Douen AG, Ramlal T, Klip A, Holloszy JO. Stimulation of glucose transport in skeletal muscle by hypoxia. J Appl Physiol (1985). 1991 Apr;70(4):1593-600. doi: 10.1152/jappl.1991.70.4.1593.

  PMID: 2055841 BACKGROUND

• Mu J, Brozinick JT Jr, Valladares O, Bucan M, Birnbaum MJ. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell. 2001 May;7(5):1085-94. doi: 10.1016/s1097-2765(01)00251-9.

  PMID: 11389854 BACKGROUND

• Louis M, Punjabi NM. Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers. J Appl Physiol (1985). 2009 May;106(5):1538-44. doi: 10.1152/japplphysiol.91523.2008. Epub 2009 Mar 5.

  PMID: 19265062 BACKGROUND

• Newhouse LP, Joyner MJ, Curry TB, Laurenti MC, Man CD, Cobelli C, Vella A, Limberg JK. Three hours of intermittent hypoxia increases circulating glucose levels in healthy adults. Physiol Rep. 2017 Jan;5(1):e13106. doi: 10.14814/phy2.13106. Epub 2017 Jan 13.

  PMID: 28087818 BACKGROUND

• Duennwald T, Gatterer H, Groop PH, Burtscher M, Bernardi L. Effects of a single bout of interval hypoxia on cardiorespiratory control and blood glucose in patients with type 2 diabetes. Diabetes Care. 2013 Aug;36(8):2183-9. doi: 10.2337/dc12-2113. Epub 2013 Mar 27.

  PMID: 23536585 BACKGROUND

• Costalat G, Lemaitre F, Tobin B, Renshaw G. Intermittent hypoxia revisited: a promising non-pharmaceutical strategy to reduce cardio-metabolic risk factors? Sleep Breath. 2018 Mar;22(1):267-271. doi: 10.1007/s11325-017-1459-8. Epub 2017 Feb 2.

  PMID: 28155101 BACKGROUND

• de Bruijn R, Richardson M, Schagatay E. Increased erythropoietin concentration after repeated apneas in humans. Eur J Appl Physiol. 2008 Mar;102(5):609-13. doi: 10.1007/s00421-007-0639-9. Epub 2007 Dec 19.

  PMID: 18097682 BACKGROUND

MeSH Terms

Conditions

Hypoxia

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Sophie Lalande

  UT Austin

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 8, 2022
• First Posted: June 16, 2022
• Study Start: October 21, 2021
• Primary Completion: September 4, 2023
• Study Completion: October 13, 2025
• Last Updated: May 6, 2026

Record last verified: 2026-05

Locations

US (1)