Early Goal-Directed Therapy Utilizing Transpulmonary Thermodilution and Severe Burn Injury

NCT05420610 | Completed

• 1 other identifier: 202101364B0
• Study Type: observational
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to optimize fluid resuscitation with transpulmonary thermodilution (TPTD)-guided protocol and to lower the mortality rate of the severely burned.

Conditions

Burns

Outcome Measures

Primary Outcomes (1)

• Patient mortality

  The primary outcome was patient mortality after major burn.

  Up to 6 months

Study Arms (1)

Patients with major burn.

Adult patients (age \> 18 years) suffered from major burn which defined as total burned surface area (TBSA) \> 20% with at least second degree burn depth were admitted to the intensive care unit (ICU) of the Burn Center at a tertiary medical center were retrospectively reviewed.

Other: Control group: Patients being admitted when The advancement of transpulmonary thermodilution(TPTD) device was unavailable.; Other: Study group: TPTD device was implemented for monitoring.

Interventions

Control group: Patients being admitted when The advancement of transpulmonary thermodilution(TPTD) device was unavailable. OTHER

The control group included patients being admitted when TPTD device was unavailable; and relatively stable patients without the need for TPTD. The adequacy of fluid resuscitation in the control group was monitored by traditional monitoring parameters including vital signs and hourly urine output.

Patients with major burn.

Study group: TPTD device was implemented for monitoring. OTHER

TPTD device was implemented for monitoring; the inclusion criteria included patients suffering from 2nd degree burn greater than 40% TBSA; a combined 2nd to 3rd degree burn greater than 30% TBSA; or patients with inhalation injury despite the burned surface area.

Patients with major burn.

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

From January 2011 to June 2019, all adult patients (age \> 18 years) suffered from major burn,23 defined as total burned surface area (TBSA) \> 20% with at least second degree burn depth were admitted to the intensive care unit (ICU) of the Burn Center at a tertiary medical center were retrospectively reviewed.

You may qualify if:

• Adult patients (age \> 18 years).
• Major burn (as total burned surface area (TBSA) \> 20% with at least second degree burn depth).
• Admitted to the intensive care unit (ICU) of the Burn Center.

You may not qualify if:

• Patients younger than 18 years old.
• Patients with severe cardiopulmonary diseases, or associated with other major trauma.
• Patient with incomplete data.

Sponsors & Collaborators

• Chang Gung Memorial Hospital: lead

Study Sites (1)

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, 83301, Taiwan

Location

MeSH Terms

Conditions

Burns

Condition Hierarchy (Ancestors)

Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 7, 2022
• First Posted: June 15, 2022
• Study Start: August 7, 2021
• Primary Completion: November 30, 2021
• Study Completion: January 20, 2022
• Last Updated: June 15, 2022

Record last verified: 2022-06

Locations

TW (1)