NCT05417581

Brief Summary

The objective of this study is to adapt the oxygraphy technique on human adipocytes and to characterize respiration measurements according to patients' body mass index and white adipose tissue localization (subcutaneous vs visceral).

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
67

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Apr 2021

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 14, 2021

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

May 17, 2022

Completed
28 days until next milestone

First Posted

Study publicly available on registry

June 14, 2022

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 12, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 12, 2023

Completed
Last Updated

October 2, 2023

Status Verified

September 1, 2023

Enrollment Period

2 years

First QC Date

May 17, 2022

Last Update Submit

September 29, 2023

Conditions

Digestive Organs--CancerBariatric Surgery CandidateParietal Region Trauma

Keywords

MitochondriaOxygraphyAdipose TissueBody Mass IndexDigestive surgery

Outcome Measures

Primary Outcomes (1)

  • Evaluation of mitochondrial respiration on adipose tissue by oxygraphy

    Mitochondrial respiration measurements in oxydophosphorylated conditions. For each patient measurements using ADP and carbohydrate or lipid substrates of the respiratory chain complexes for both the subcutaneous and the visceral tissue.

    day 1

Secondary Outcomes (3)

  • mitochondrial respiration values depending on patients BMI by oxygraphy

    day 1

  • comparing mitochondrial respiration values depending on tissue location by oxygraphy

    day 1

  • comparing mitochondrial respiration values depending on anthropometric data by oxygraphy

    day 1

Study Arms (1)

All patients

EXPERIMENTAL

a sample of adipose tissue will be collected during the scheduled surgery

Procedure: adipose surgery

Interventions

adipose surgeryPROCEDURE

A quantity of adipose tissue equivalent to 10-20 cubic centimeter will be removed subcutaneously and from the omentum during surgical procedures (oncological, bariatric)

All patients

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients undergoing oncological, bariatric, parietal surgery
  • Patients able to give an informed consent
  • Patients affiliated to an Health Care insurance
  • Patients aged over 18

You may not qualify if:

  • Patients under guardianship, curatorship or deprived of freedom
  • Pregnant or breastfeeding women
  • Participation refusal
  • Patients under chemotherapy
  • Patients with peritonitis and infectious parietal processes

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU clermont-ferrand

Clermont-Ferrand, France

Location

Related Publications (1)

  • Guerrier L, Bacoeur-Ouzillou O, Touron J, Mezher S, Cassagnes L, Vieille-Marchiset A, Chanon S, Pereira B, Pezet D, Pinel A, Gagniere J, Malpuech-Brugere C, Richard R. Mitochondrial respiration in white adipose tissue is dependent on body mass index and tissue location in patients undergoing oncological or parietal digestive surgery. FASEB J. 2025 Jan 31;39(2):e70350. doi: 10.1096/fj.202402243R.

    PMID: 39856788DERIVED

MeSH Terms

Conditions

Craniocerebral Trauma

Condition Hierarchy (Ancestors)

Trauma, Nervous SystemNervous System DiseasesWounds and Injuries

Study Officials

  • Ruddy RICHARD

    University Hospital, Clermont-Ferrand

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
SINGLE GROUP
Model Details: all participants receive the same intervention
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 17, 2022

First Posted

June 14, 2022

Study Start

April 14, 2021

Primary Completion

April 12, 2023

Study Completion

April 12, 2023

Last Updated

October 2, 2023

Record last verified: 2023-09

Locations

FR(1)