Impact Of Post-Bariatric Body Contouring Procedures on Patient Body Weight and Metabolism

NCT05034081 | Completed Results DMC

• 1 other identifier: AUN
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Is post-bariatric body contouring surgery prevent weight regain or no, and what is the effect on the patient's Metabolism? Few literature studies report body contouring surgery to be positively associated with maintained weight loss after obesity surgery but the measures of outcomes are diverse, and the collective magnitude of such an association is unknown. The changes in gastrointestinal hormones, adipokines, and cytokines as well as in hypothalamic neuropeptides and neurotransmitters resemble the changes observed in the anorexia/cachexia, suggesting that bariatric surgery triggers a catabolic state responsible for loss of appetite and prolonged body weight reduction. Weight regain after gastric bypass surgery occurs in about half of all patients within 2 years. About 50% of patients eventually gain a little weight back after hitting their low point. We need a more thorough evaluation to determine what factors - medical, psychological, lifestyle - are involved in the weight gain. One of the factors that seem to be responsible for the degree and durability of weight loss is post-bariatric body contouring procedures. However, metabolic consequences of removing excess subcutaneous adipose tissue by body contouring procedures have to a lesser extent been explored

Conditions

Bariatric Surgery Candidate

Keywords

Bariatric; Weight regain; Metabolism

Outcome Measures

Primary Outcomes (4)

• Weight Changes by Kilograms

  to know the effect of post-bariatric body contouring surgery in weight. Detect the weight cahnges of the patient 3 and 6 months after body contouring surgery and body mass index also measured

  6 months

• Level of Tumor Necrotizing Factor Alfa in Blood

  Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. Tumor necrotizing factor alfa increase afer bariatric surgery and we want to know if its complete on increasing after body contouring surgeries or decresae . Tnf-a is measured by pg/ml

  6 months

• Level of BNP in Blood

  Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. BNP highly increase with catabolism after bariatric surgery and we want to know the effect of body contouring surgeries in the level of BNP. BNP unit is pg/ml

  6 months

• Level of High Sensitive CRP in Blood

  Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. hsCRP increase with catabolism after bariatric surgery and we want to know the effect of body contouring surgeries in blood level of hsCRp. The unit of hsCRP is mg/dl.

  6 months

Secondary Outcomes (1)

• Patient Satisfaction Score

  6 months

Study Arms (2)

group A

EXPERIMENTAL

to know the effect of post-bariatric body contouring surgery on weight loss and metabolism

Procedure: body contouring

group B

NO INTERVENTION

compare this group of patients with group A to detect weight changes and metabolic changes without any post-bariatric intervention

Interventions

body contouring PROCEDURE

any post-bariatric body contouring surgery included

group A

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Post-bariatric (sleeve) patients will do body contouring surgery.
• Post-bariatric patients has been stable within 5 kg for 3 months
• Age between 20-60 years old.
• patients use the determinant fixed diet.

You may not qualify if:

• Age below 20 and above 60 years old.
• Non-compliance with the fixed diet.
• psychotic patients.
• Female patients seeking pregnancy.
• Endocrine causes of obesity.
• Bariatric surgery other than sleeve.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University

Asyut, Asyut Governorate, 088, Egypt

Location

MeSH Terms

Interventions

Body Contouring

Intervention Hierarchy (Ancestors)

Cosmetic Techniques; Therapeutics; Plastic Surgery Procedures; Surgical Procedures, Operative

Results Point of Contact

• Title: MOHAMED Shadad rateb
• Organization: AssiutU

m_shadad@aun.edu.eg

00201020575457

Study Officials

• Mohamed Shadad, Master

  Assiut University

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer

Study Record Dates

• First Submitted: August 18, 2021
• First Posted: September 5, 2021
• Study Start: September 1, 2021
• Primary Completion: August 15, 2024
• Study Completion: August 15, 2025
• Last Updated: May 1, 2026
• Results First Posted: May 1, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)