NCT05417152

Brief Summary

In this clinical study the Notal Vision Home OCT (NVHO) Monitoring System will be used to evaluate the ability of patients diagnosed with DME to perform sequential self-images of their eyes with the self-operated NVHO device in a home simulated environment in the doctor's office. The study population will include up to 30 patients, with DR in at least one eye at the time of enrollment. All subjects will be enrolled at one site in Israel.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
18

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jun 2022

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 9, 2022

Completed
5 days until next milestone

First Posted

Study publicly available on registry

June 14, 2022

Completed
15 days until next milestone

Study Start

First participant enrolled

June 29, 2022

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2022

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 30, 2023

Completed
Last Updated

June 15, 2023

Status Verified

June 1, 2022

Enrollment Period

5 months

First QC Date

June 9, 2022

Last Update Submit

June 14, 2023

Conditions

Outcome Measures

Primary Outcomes (7)

  • NVHO Total Retinal Fluid (TRF)

    volume (nl) measured by NOA (automatic OCT analyzer)

    5 minutes

  • NVHO Intra-Retinal Fluid (IRF)

    volume (nl) measured by NOA (automatic OCT analyzer)

    5 minutes

  • NVHO Sub-Retinal Fluid (SRF)

    volume (nl) measured by NOA (automatic OCT analyzer)

    5 minutes

  • Zeiss Cirrus OCT Total Retinal Fluid (TRF)

    volume (nl) measured by a human reader

    10 minutes

  • Zeiss Cirrus OCT Intra-Retinal Fluid (IRF)

    volume (nl) measured by a human reader

    10 minutes

  • Zeiss Cirrus OCT Sub-Retinal Fluid (SRF)

    volume (nl) measured by a human reader

    10 minutes

  • Scanning session completion status

    complete/incomplete

    5 minutes

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

The study population will include up to thirty (30) patients, with DR in at least one eye at the time of enrollment. All subjects will be enrolled at one (1) site in Israel. The subjects must meet all inclusion / exclusion criteria. Approximately 90% of the enrolled subjects should have at least one eye with DME at the time of enrollment.

You may qualify if:

  • Ability to speak, read and understand Hebrew.
  • Ability to understand and agree to contents of informed consent.
  • Eighteen (18) years of age or older at the time of Informed Consent.
  • Subjects diagnosed with DR (Diabetic Retinopathy) in at least one eye, with or without DME
  • Best corrected Visual Acuity of 20/320 (6/96) or better in eyes participating at the study.

You may not qualify if:

  • Subjects with dilated pupils.
  • Subjects with other retinal disease requiring steroidal or anti-VEGF injections.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Assuta Hashalom

Tel Aviv, Israel

Location

MeSH Terms

Conditions

Diabetic Retinopathy

Condition Hierarchy (Ancestors)

Retinal DiseasesEye DiseasesDiabetic AngiopathiesVascular DiseasesCardiovascular DiseasesDiabetes ComplicationsDiabetes MellitusEndocrine System Diseases

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 9, 2022

First Posted

June 14, 2022

Study Start

June 29, 2022

Primary Completion

November 30, 2022

Study Completion

March 30, 2023

Last Updated

June 15, 2023

Record last verified: 2022-06

Locations