Sentence Production Training in Aphasia

NCT05415501 | Recruiting

• 1 other identifier: IRB-2021-659
• Study Type: interventional
• Target: 104
• Locations: 1 country
• Sites: 1

Brief Summary

This project focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which learning conditions are most effective in creating maximal training gains. Then, in a later study, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the studies.

Conditions

Aphasia

Keywords

aphasia training; aphasia treatment; sentences; grammar

Outcome Measures

Primary Outcomes (3)

• Production of target sentences on action description pictures

  Production accuracy (percent correct)

  From baseline up to 1-week post training or 2-month post treatment

• Comprehension of target sentences in a sentence-to-picture matching task

  Comprehension accuracy (percent correct)

  From baseline up to 1-week post training or 2-month post treatment

• Real-time comprehension of target sentences in a sentence-to-picture matching task

  Changes in eye fixations to the target picture

  From baseline up to 1-week post training or 2-month post treatment

Secondary Outcomes (3)

• Production of untrained sentences

  From baseline up to 2-month post treatment

• Connected speech production - story retell

  From baseline up to 2-month post treatment

• Connected speech production - picture description

  From baseline up to 2-month post treatment

Study Arms (1)

Structural priming training

EXPERIMENTAL

Participants will be enrolled in 3 sessions of structural priming training (for experiment 1-3) or up to 15 treatment sessions (for experiment 4). Each session will be about 2 hour long, consisting of a set of tasks, including repeating, making, and remembering various types of sentences. In experiment 1-3, each participant will receive two different experimental priming conditions that are being compared within each session. In experiment 4, participants will receive a structural priming treatment in a single-subject design.

Behavioral: Sentence training

Interventions

Sentence training BEHAVIORAL

Participants will be trained to read, make, and recall sentences during each session.

Structural priming training

Eligibility Criteria

• Age: 21 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals with post-stroke aphasia
• At least 6 months post-onset of eft hemisphere stroke
• Native speaker of English
• Normal or corrected to normal hearing and vision
• High-school educated
• Difficulty communicating in sentences, with some ability to use words independently

You may not qualify if:

• Severe apraxia of speech
• Other neurological conditions affecting communication (e.g., dementia)
• Uncontrolled psychiatric/psychological conditions affecting thinking and communication
• Active alcohol/substance abuse

Sponsors & Collaborators

• Purdue University: lead
• Temple University: collaborator
• University of California, San Diego: collaborator

Study Sites (1)

Purdue University

West Lafayette, Indiana, 47907, United States

RECRUITING

MeSH Terms

Conditions

Aphasia

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Jiyeon Lee, PhD

  Purdue University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jiyeon Lee, PhD

CONTACT

7654943810; lee1704@purdue.edu

Jiyeon Lee

CONTACT

7654943810; lee1704@purdue.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: May 16, 2022
• First Posted: June 13, 2022
• Study Start: August 1, 2021
• Primary Completion: May 30, 2026
• Study Completion: May 30, 2026
• Last Updated: December 18, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ANALYTIC CODE
• Time Frame: Starting 6 months after publication
• Access Criteria: Researchers of OSF will access the study materials or data made available via OSF. Deidentified individual data can also be shared with other researchers upon requests and the PI will review each request. Other supporting materials such as study stimuli or protocols will be shared with other researchers upon request.

Locations

US (1)