NCT05414812

Brief Summary

The purpose of this study is to evaluate the effectiveness of a multi-component intervention to improve young breast cancer survivors' engagement in goal-concordant oncofertility care, concurrently with observing and gathering information on how the intervention is implemented. The investigators hypothesize that implementation of the intervention will result in increased young breast cancer survivors' engagement in goal-concordant oncofertility care.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
81

participants targeted

Target at P25-P50 for not_applicable breast-cancer

Timeline
Completed

Started Oct 2021

Geographic Reach
1 country

4 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 15, 2021

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

May 25, 2022

Completed
16 days until next milestone

First Posted

Study publicly available on registry

June 10, 2022

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2024

Completed
Last Updated

January 10, 2025

Status Verified

November 1, 2024

Enrollment Period

2.5 years

First QC Date

May 25, 2022

Last Update Submit

January 8, 2025

Conditions

Keywords

Oncofertility

Outcome Measures

Primary Outcomes (1)

  • Medical record review of engagement in goal-concordant oncofertility care

    Study staff will be trained to abstract the primary outcome of engagement in goal-concordant oncofertility care from the patient's medical records using standardized case report forms. Engagement in goal-concordant oncofertility care will be assigned to young breast cancer survivors who undergo: 1) oncofertility needs screen, complete a navigation session, receive the women's health survivorship care plan (SCP), and thereafter have no oncofertility needs; OR 2) oncofertility needs screen, complete a navigation session, receive the SCP, have an oncofertility need, undergo telehealth oncofertility consultation, and thereafter have no oncofertility services needs; OR 3) oncofertility needs screen, complete a navigation session, receive the SCP, have an oncofertility need, undergo telehealth oncofertility consultation, have an oncofertility services need, and thereafter uptake appropriate services.

    12 weeks after oncology visit

Study Arms (2)

Multi-component oncofertility care intervention

EXPERIMENTAL

After the intervention implementation, all breast cancer patients presenting to oncology clinical visits that meet eligibility criteria will receive the multi-component oncofertility care intervention.

Behavioral: Multi-component oncofertility care intervention

Usual Care

NO INTERVENTION

Prior to the intervention implementation, all breast cancer patients presenting to oncology clinical visits that meet eligibility criteria will receive usual care.

Interventions

The intervention includes: 1. Young breast cancer patients presenting to oncology visits will complete a clinic-based oncofertility needs screen with a member of the clinical team. This needs screen assesses i) desire to have a child in the future, ii) need for contraception, and iii) sexual health/menopause symptoms. 2. A women's health survivorship care plan (SCP) in Spanish and English encompasses content on screening and management strategies for a) fertility concerns/pregnancy health; b) contraception; c) hot flashes and d) sexual health. 3. Oncofertility navigation consists of one telehealth or in-person session with a social worker to: i) assess the patient's oncofertility needs, ii) review the women's health SCP, iii) provide support with the goal of engaging in oncofertility care. 4. Oncofertility consultation as indicated via telehealth or in person will occur between the patient and reproductive specialist. Each consultation is estimated to be 1 hour.

Multi-component oncofertility care intervention

Eligibility Criteria

Age18 Years - 50 Years
Sexfemale(Gender-based eligibility)
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Breast cancer (Stages 0-IV) diagnosis
  • Primary language English or Spanish
  • Receiving oncology care at participating clinical sites
  • Living in Imperial County, California

You may not qualify if:

  • \- Women who are pregnant at recruitment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Pioneers Medical Health District

Brawley, California, 92227, United States

Location

Cancer Resource Center of the Desert

El Centro, California, 92243, United States

Location

El Centro Regional Medical Center

El Centro, California, 92243, United States

Location

University of California San Diego

La Jolla, California, 92093, United States

Location

Related Publications (1)

  • Romero SAD, Palomino H, Ahmed SH, Peacher D, Urias A, Ramirez L, Yocupicio J, Gutierrez P, Flores Ortega RE, Reyes B, Kaiser BN, Hoyt H, Su HI. Intervening on women's health for rural young breast cancer survivors: A study protocol. Contemp Clin Trials. 2023 Jul;130:107215. doi: 10.1016/j.cct.2023.107215. Epub 2023 May 8.

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Study Officials

  • H. Irene Su, MD, MSCE

    University of California, San Diego

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
SEQUENTIAL
Model Details: Interrupted time series design
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

May 25, 2022

First Posted

June 10, 2022

Study Start

October 15, 2021

Primary Completion

April 30, 2024

Study Completion

April 30, 2024

Last Updated

January 10, 2025

Record last verified: 2024-11

Data Sharing

IPD Sharing
Will share

Deidentified individual participant data generated during the study will be available from the principal investigator (H. Irene Su) upon reasonable request.

Shared Documents
STUDY PROTOCOL, SAP, ICF
Time Frame
Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication.
Access Criteria
Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to the principal investigator (H. Irene Su).

Locations