Chiropractic T Cell Study

NCT05412602 | Completed

• 1 other identifier: H21-00643
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

Some studies suggest that specific chiropractic care (techniques known as "spinal manipulation therapy") can have benefits to the immune system but studies are scarce, sample sizes small, and methodology and analyses often not of the highest scientific standards. The investigators will example how 36 sessions of chiropractic care over 9-12 weeks can impact immune cell function using a randomized clinical trial design.

Conditions

Intervention; Waitlist Control

Outcome Measures

Primary Outcomes (1)

• Change in CD25+ Regulatory T Cell

  CD25+ Regulatory T Cell count will be measured by surface staining using flow cytometry

  12 weeks

Secondary Outcomes (1)

• Change in CD4+ and CD8+ T cell

  12 weeks

Other Outcomes (9)

• Changes in TNF alpha secretion

  12 weeks

• Changes in IFN gamma secretion

  12 weeks

• Change in body mass

  12 weeks

Study Arms (2)

Intervention

EXPERIMENTAL

experimental group will receive 36 chiropractic treatments designed to correct vertebral subluxation over \~12 weeks

Procedure: full spine corrective protocol

waitlist control

NO INTERVENTION

waitlist control will receive no chiropractic interventions and will be reminded that to successfully complete their condition, they do not seek alternative chiropractic treatments

Interventions

full spine corrective protocol PROCEDURE

36 chiropractic adjustments over 12 weeks (3 visits per week) with in office spinal traction on the 3D Denneroll Traction Table, as well as supplemental home exercises

Intervention

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Must be between the ages of 18-70.
• Must exhibit vertebral subluxation as measured by a misalignment between one or more vertebrae in relation to normal spinal alignment.
• Have not been sick for the past 3 weeks (immune function).
• Non-smoker.
• Must be able to fast for 10-12 hours.

You may not qualify if:

• To have had a chiropractic intervention within the past 6 months.
• To have a condition that may limit the ability to apply a high velocity, low amplitude (HVLA) thrust to the spine such as but not limited to ligament damage, reduced bone density, or other factors that weaken the body's ability to withstand reasonable care (bone cancer, fractures, osteoporosis, etc.)
• To have excessive scoliotic curvature of the spine (\> 30º) as measured by identifying the first vertebrae, and the most laterally displaced vertebrae that exhibits tilt below it.

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

University of British Columbia Okanagan

Kelowna, British Columbia, V1V 1V7, Canada

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: parallel-arm randomized control trial

Study Record Dates

• First Submitted: June 6, 2022
• First Posted: June 9, 2022
• Study Start: July 25, 2022
• Primary Completion: September 1, 2023
• Study Completion: December 31, 2023
• Last Updated: February 10, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)