Clinical Characteristics, Management Patterns and Outcomes of Type A Aortic Dissection: A Sino-US Comparative Cohort Analysis

NCT05409469 | Completed DMC

• 1 other identifier: NanjingFirst AAD
• Study Type: observational
• Target: 11,550
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study constructed a retrospective cohort study by retrospectively analyzing the data of all patients with aortic dissection from January 1, 2012 to December 31, 2021 from the Cardiovascular Disease Registration System of Jiangsu Province in China and the data of similar diseases in recent years from National Inpatient Sample database in the United States

Conditions

Aortic Dissection

Keywords

Aortic Dissection; China; the United States

Outcome Measures

Primary Outcomes (2)

• Baseline data of patients with type A aortic dissection was assessed by SPSS 17.0

  Baseline data of patients with type A aortic dissection included gender, age,height, weight, past medical history, family history, hospital costs, etc.

  from 2015 to 2019

• The main efficacy indicators was assessed by SPSS 17.0.

  The main efficacy indicators included surgical procedures, surgical outcome (postoperative bleeding, ICU stay, extubation time), perioperative complications (including infection, bleeding, neurological complications, cardic complications, renal insufficiency, etc.), and postoperative mortality.

  from 2015 to 2019

Study Arms (2)

Chinese patients with aortic dissection

Clinical characteristics, management patterns and outcomes of type A aortic dissection in China.

Procedure: surgery

American patients with aortic dissection

Clinical characteristics, management patterns and outcomes of type A aortic dissection in the United States.

Procedure: surgery

Interventions

surgery PROCEDURE

surgery on patients with aortic dissection

American patients with aortic dissection; Chinese patients with aortic dissection

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients with aortic dissection in Jiangsu Aortic Registry system of China from January 2012 to December 2021 and all patients with aortic dissection in National Inpatient Sample database of the United States from January 2015 to December 2019.

You may qualify if:

• Clinical diagnosis of type A Aortic Dissection

You may not qualify if:

• age\<18, age unknown,
• diagnosis of aortic aneurysm, transfer out within 1 day,
• unknown vital status at discharge;
• unknown treatment type: cardioplegia, valve or cardiac repair only without aortic repair or two types of treatments on different days

Sponsors & Collaborators

• Xin Chen: lead
• China Medical University, China: collaborator

MeSH Terms

Conditions

Aortic Dissection

Interventions

Surgical Procedures, Operative

Condition Hierarchy (Ancestors)

Dissection, Blood Vessel; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Acute Aortic Syndrome; Aortic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: May 20, 2022
• First Posted: June 8, 2022
• Study Start: January 1, 2012
• Primary Completion: December 1, 2021
• Study Completion: December 1, 2021
• Last Updated: June 8, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share