AGC Mode vs Minimal Flow in Breast Surgery

NCT05404269 | Completed

• 1 other identifier: 2021/05-12
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to compare the AGC mode and manually controlled minimal-flow anesthesia for volatile anesthetic consumption, hemodynamic parameters, and recovery from anesthesia

Conditions

Volatil Agent Consumption; Automatic End-tidal Controlled Anesthesia; Anesthesia; Functional; Breast Diseases

Keywords

anesthesia machine; sevoflurane; minimal fresh gas flow; breast surgery; AGC mode

Outcome Measures

Primary Outcomes (1)

• Consumption of Volatile Agent

  Difference of Sevoflurane Consumption between the groups

  during the surgery

Study Arms (3)

Group AGC

The FLOW-i anesthesia machine (Maquet, Solna, Sweden) can be equipped with automated gas control (AGC), an automated low flow tool with target control of the inspired oxygen concentration (FIO2) and end-expired concentration (FA) of a potent inhaled anesthetic. İnitially before induction, we set the minimal fresh gas flow to 0.5 L min-1 and target end-expired agent concentration for 1 MAC (minimal alveolar concentration). Shortly after intubation of the patient, we switched to AGC mode.

Device: AGC mode

Group Minimal Flow

İn this group; following intubation, we set the fresh gas flow to 4 L min-1 and than we readjusted fresh gas flow manually to 0.5 L min-1 after sevoflurane concentration reaching to 1 MAC.

Group Medium Flow

İn this group; following intubation, we set the fresh gas flow to 4 L min-1 and than we readjusted fresh gas flow manually to 2 L min-1 after sevoflurane concentration reaching to 1 MAC.

Interventions

AGC mode DEVICE

Automated Gas Control mode at Maquet FLOW-i anesthesia machine

Group AGC

Eligibility Criteria

• Age: 18 Years - 65 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Between 18-65 years, female patients underwent breast surgery

You may qualify if:

• years
• undergoing breast surgery
• ASA physical status I-II
• female
• operation lasting at least 1 hour
• those who agreed to volunteer for the study with an informed consent form

You may not qualify if:

• coronary artery disease, CHF
• pregnancy or breastfeeding women
• decompensated diabetes mellitus
• kidney or liver failure
• chronic obstructive pulmonary disease
• opioid sensitivity
• history of malignant hyperthermia
• history of smoking
• alcohol or drug addiction
• significant anemia
• sepsis
• BMI \>35
• patients with allergies to the drugs used in the study

Sponsors & Collaborators

• Zonguldak Bulent Ecevit University: lead

Study Sites (1)

Zonguldak Bülent Ecevit University Medicine Faculty

Zonguldak, Kozlu, 67600, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Breast Diseases

Condition Hierarchy (Ancestors)

Skin Diseases; Skin and Connective Tissue Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiologist

Study Record Dates

• First Submitted: May 30, 2022
• First Posted: June 3, 2022
• Study Start: March 15, 2021
• Primary Completion: March 15, 2022
• Study Completion: April 4, 2022
• Last Updated: June 3, 2022

Record last verified: 2022-05

Locations

TU (1)