Effect of Topical Application of Hyaluronic Acid on Stability of Immediate Loading Dental Implant in Posterior Maxilla

NCT05403099 | Completed

• 1 other identifier: 01010119
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Effect of Topical Application of Hyaluronic Acid on Stability of Immediate Loading Dental Implant in Posterior Maxilla

Conditions

Missing Teeth

Keywords

Hyaluronic Acid, dental implant

Outcome Measures

Primary Outcomes (5)

• implant stability

  using radiofrequency analysis

  immediately after surgery

• implant stability

  using radiofrequency analysis

  one month

• implant stability

  using radiofrequency analysis

  three months

• implant stability

  using radiofrequency analysis

  six months

• bone density

  bone density around the implant is measured in cone beam computed tomography

  three months

Secondary Outcomes (2)

• propping depth

  six months

• bleeding inex

  six months

Study Arms (2)

control

ACTIVE COMPARATOR

Each implant was placed into the prepared implant site.

Other: conventional implant placement

Hyaluronic acid

EXPERIMENTAL

Each implant was placed after topical application of HA on its surface

Other: Hyaluronic acid

Interventions

Hyaluronic acid OTHER

immediate placement of dental implant after topical application of hyaluronic acid on implant surface

Hyaluronic acid

conventional implant placement OTHER

immediate placement of dental implant without application of hyaluronic acid on implant surface

control

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Highly motivated patients with good oral hygiene.
• Age 18 years or older.
• Adequate alveolar bone volume at the implant site, at least 6mm in width and 15 mm in height.
• Free from any parafunctional habits

You may not qualify if:

• Patients suffering from any systemic or local disease that contraindicate implant placement or surgery.
• Pregnancy.
• Smokers.

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Merna Elhadidi

Al Mansurah, Egypt

Location

MeSH Terms

Conditions

Anodontia

Interventions

Hyaluronic Acid

Condition Hierarchy (Ancestors)

Tooth Abnormalities; Stomatognathic System Abnormalities; Stomatognathic Diseases; Tooth Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Glycosaminoglycans; Polysaccharides; Carbohydrates

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Twenty implants were inserted in patients seeking for replacement of missed single or multiple posterior maxillary teeth. Patients were divided randomly into two groups. In the control group, ten implants were placed and immediately loaded. While in the study group, ten implants were coated with hyaluronic acid (HA) immediately before placement and immediately loaded. All patients were clinically evaluated at implant placement time, one, three and six months after loading regarding implant stability. Peri-implant pocket depth and modified sulcus bleeding index were evaluated clinically at six months in all patients. Bone density was evaluated radiographically after three months. All clinical and radiographic data were subjected to statistical analysis.

Study Record Dates

• First Submitted: May 20, 2022
• First Posted: June 3, 2022
• Study Start: March 1, 2019
• Primary Completion: March 1, 2020
• Study Completion: March 1, 2020
• Last Updated: June 3, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)