NCT05399056

Brief Summary

Chronic Obstructive Pulmonary Disease (COPD) affects approximately 16 million Americans and is characterized by recurrent exacerbations that lead to 1.5 million Emergency Department visits and 700,000 hospitalizations annually. Pulmonary rehabilitation (PR) is a structured program of exercise and self-management support that has been proven to relieve shortness of breath and increase quality of life when initiated after an exacerbation, but unfortunately, few eligible patients participate. This project will compare the effectiveness of two novel strategies - one involving video narratives of other patients telling their story of how they overcame challenges and completed PR, the other involving telephonic peer coaching with an individual with lived experience - to enhanced usual care, and to each other, at increasing patient participation in PR after an exacerbation.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
305

participants targeted

Target at P75+ for not_applicable chronic-obstructive-pulmonary-disease

Timeline
4mo left

Started Feb 2023

Longer than P75 for not_applicable chronic-obstructive-pulmonary-disease

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress91%
Feb 2023Aug 2026

First Submitted

Initial submission to the registry

May 24, 2022

Completed
8 days until next milestone

First Posted

Study publicly available on registry

June 1, 2022

Completed
9 months until next milestone

Study Start

First participant enrolled

February 24, 2023

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 28, 2026

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2026

Expected
Last Updated

December 12, 2025

Status Verified

March 1, 2025

Enrollment Period

3 years

First QC Date

May 24, 2022

Last Update Submit

December 9, 2025

Conditions

Keywords

COPDPulmonary rehabilitationStorytellingPeer coachingmotivational interviewingBehavioral interventionschronic obstructive pulmonary disease

Outcome Measures

Primary Outcomes (1)

  • Number of Pulmonary Rehabilitation (PR) sessions: Completion of ≥6 PR sessions within 6 months of randomization

    6 months

Secondary Outcomes (3)

  • Any attendance (yes/no) at PR within 6 months of randomization.

    6 months

  • Total number of PR sessions completed within 6 months of randomization.

    6 months

  • Time to first PR session attended

    6 months

Other Outcomes (16)

  • Change in Modified Medical Research Council (mMRC) dyspnea scale from randomization to 6 months

    6 months

  • Change in Clinical COPD Questionnaire (CCQ) from randomization to 6 months

    6 months

  • Change in Hospital Anxiety and Depression Scale (HADS) from randomization to 6 months

    6 months

  • +13 more other outcomes

Study Arms (3)

Enhanced usual care

NO INTERVENTION

Enhanced usual care describes a process in which automated surveillance is used to identify individuals experiencing a COPD exacerbation. This is followed by direct outreach - either through in-person visits while a patient is hospitalized, or by mail and telephone in the outpatient setting, to facilitate referral to PR. Subjects randomized to this arm will be given a pamphlet describing the benefits of PR.

Enhanced usual care + Storytelling

ACTIVE COMPARATOR

Subjects randomized to the eUC + Storytelling intervention will view the video narrative(s) of one or more individuals with COPD who has overcome similar barriers and has attended a program of PR. Subjects will be shown the first chapter of the story immediately after randomization and will receive email and/or text messages to prompt viewing of subsequent chapters at 2 weeks, 1 month, 2 months, 3 months and 5 months. Emails and text messages will include a link to a REDCap document that contains a set of embedded video clips representing the next chapter in each storyteller's narrative.

Behavioral: Storytelling

Enhanced usual care + Peer support

ACTIVE COMPARATOR

Subjects randomized to the eUC + Peer support intervention will be matched with a peer coach of the same gender, race, and approximate age. For those enrolled during a hospitalization, coaches will be instructed to attempt the initial phone contact prior to the patient's discharge; for patients enrolled after an ED visit or outpatient exacerbation, coaches will be instructed to contact the patients within 72 hours of randomization. Peer coaches will be asked to complete at least one call each week during months 1-2, biweekly calls during months 3-4, and monthly calls during months 5-6. Coaches will be asked to follow a conversation guide, provided during the initial training, to structure phone conversations with their paired patient.

Behavioral: Telephonic Peer Coaching

Interventions

StorytellingBEHAVIORAL

Video narratives of an individual with lived experience with COPD and Pulmonary Rehabilitation describing their journey through Pulmonary Rehabilitation

Enhanced usual care + Storytelling

Telephonic Peer Coaching from an individual with lived experience with COPD and Pulmonary Rehabilitation trained in motivational interviewing

Enhanced usual care + Peer support

Eligibility Criteria

Age40 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years or older
  • Received treatment for COPD exacerbation in either inpatient or outpatient setting
  • Referred for pulmonary rehabilitation
  • Ability to understand and communicate in English
  • Willingness to participate in calls with peer coach and to view storytelling videos
  • Working phone

You may not qualify if:

  • Unwilling to attend PR
  • Not eligible for PR based on spirometry or other clinical contraindications as determined by PR staff
  • Currently enrolled in, or completion of 12 or more sessions of PR in the past
  • Comfort measures only or Hospice care
  • Resident of long-term care facility
  • Unable or unwilling to give informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Baystate Health

Springfield, Massachusetts, 01199, United States

RECRUITING

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Peter Lindenauer, MD, MSc

    Baystate Health

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
Outcomes will be collected by a member of the research staff blinded to participant treatment arm
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 24, 2022

First Posted

June 1, 2022

Study Start

February 24, 2023

Primary Completion

February 28, 2026

Study Completion (Estimated)

August 31, 2026

Last Updated

December 12, 2025

Record last verified: 2025-03

Data Sharing

IPD Sharing
Will share

We will share deidentified individual participant data upon receipt and approval of research question and analysis plan from a researcher; or for teaching purposes.

Shared Documents
STUDY PROTOCOL, SAP, ICF
Time Frame
We will share deidentified IPD based on our criteria within 3 months after publication of our study results in scientific journals without any time limit to share thereafter.
Access Criteria
Access will be based on receipt of research question/s and analysis strategies planned by a researcher. Approval to access the deidentified IDP will be granted to the researcher if deemed relevant by the study PI.

Locations