Factors Associated With Decisions to Withhold or Withdraw Intensive Care

NCT05394961 | Completed

• 1 other identifier: Uppsala University
• Study Type: observational
• Target: 33,256
• Locations: 1 country
• Sites: 1

Brief Summary

Medical and socioeconomic data are extracted from the Swedish Intensive Care Registry (SIR), the Swedish National Patient Registry and Statistics Sweden for all adult patients admitted to in Swedish intensive care units between 2014-01-01 and 2020-12-31 with a diagnosis of sepsis and/or acute respiratory distress syndrome (ARDS) and/or coronavirus 19 (COVID-19) infection, and registered in SIR. The impact of demographic and socioeconomic factors on decisions to withhold or withdraw intensive care, and on mortality, are studied and statistically adjusted for level of chronic comorbidity and severity of acute illness.

Conditions

Sepsis; ARDS, Human; COVID-19

Keywords

critical care; limitations of care; critical illness; intensive care unit

Outcome Measures

Primary Outcomes (1)

• Decision to withhold or withdraw intensive care

  Registered decision

  During ICU care

Secondary Outcomes (2)

• 30 day mortality

  30 days

• 90 day mortality

  90 days

Interventions

Treatment in an intensive care unit with a diagnosis of sepsis and/or ARDS and/or covid-19 PROCEDURE

As above

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The population consists of an absolute majority of the patients treated in Swedish intensive care units with the relevant diagnoses during the study period and can therefore be considered a nationwide population rather than a sample thereof.

You may qualify if:

• Registered intensive care episode with relevant diagnosis

Sponsors & Collaborators

• Uppsala University: lead

Study Sites (1)

Uppsala University, department of Surgical Sciences

Uppsala, 75185, Sweden

Location

MeSH Terms

Conditions

Sepsis; Respiratory Distress Syndrome; COVID-19; Critical Illness

Interventions

Therapeutics

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Lung Diseases; Respiratory Tract Diseases; Respiration Disorders; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Disease Attributes

Study Officials

• Miklós Lipcsey, MD, PhD

  Upsala University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 23, 2022
• First Posted: May 27, 2022
• Study Start: August 26, 2021
• Primary Completion: August 26, 2021
• Study Completion: August 26, 2021
• Last Updated: May 27, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)