Intravoxel Incoherent Motion (IVIM) Magnetic Resonance Imaging in Multiple Sclerosis

NCT05391906 | Active Not Recruiting DMC

• 1 other identifier: TiffanySo
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Intravoxel incoherent motion (IVIM) is technique based on diffusion-weighted imaging (DWI). In this study, the investigators evaluate the use of IVIM in patients with Multiple Sclerosis.

Conditions

Multiple Sclerosis

Outcome Measures

Primary Outcomes (1)

• IVIM parameters (including ADC,D,D*,f) in Multiple Sclerosis brain regions.

  Primary Outcome Measure: 1\. IVIM parameters (including ADC,D,D\*,f) in Multiple Sclerosis brain regions. The parameters are calculated based on a IVIM model bi-exponential model represented by: S(b)/S(0)=f ×exp(-bD\*)+ (1-f)×exp(-bD), and the mono-exponential model for ADC calculation as represented by: S(b)/S(0)=exp(-bADC), where S(b) and S (0) are the MRI signal intensities at a given b value and b = 0, respectively. ADC: apparent diffusion coefficient. ADC is expressed in units of mm2/s. f: the perfusion or (micro) vascular volume fraction which depends on capillary geometry and blood velocity. f is expressed in units of mm2/s. D\*: pseudo diffusion coefficient that resembles the perfusion related incoherent microcirculation. D\* is expressed in units of mm2/s. D: pure diffusion coefficient which is related to pure molecular diffusion. D is expressed in units of mm2/s.

  Up to 2 months

Study Arms (1)

Intravoxel Incoherent Motion(IVIM) MRI

EXPERIMENTAL

Intravoxel incoherent motion (IVIM) is based on diffusion-weighted imaging (DWI)

Other: Diffusion-weighted magnetic resonance imaging

Interventions

Diffusion-weighted magnetic resonance imaging OTHER

Diffusion-weighted magnetic resonance imaging

Also known as: Diffusion-weighted magnetic resonance imaging uses the diffusion of water molecules to generate contrast in MR images.

Intravoxel Incoherent Motion(IVIM) MRI

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who are 18 years or older.
• Relapsing-remitting MS diagnosed as per Macdonald criteria

You may not qualify if:

• Contraindication to MRI. For example, metal implantation in the body, claustrophobia and pregnancy.
• Patients who are unable to tolerate the scans without moving the head as a result of symptoms such as tremor, spasticity, involuntary movements and spasms, cognitive impairment, coughing, and shortness of breath.

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

CUHK

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Assistant Professor

Study Record Dates

• First Submitted: May 3, 2022
• First Posted: May 26, 2022
• Study Start: January 30, 2023
• Primary Completion (Estimated): December 20, 2026
• Study Completion (Estimated): December 30, 2026
• Last Updated: March 12, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)