Peri-implant Marginal Bone Loss and Implant Failure in Patients With Smoking Habit

NCT05390242 | Unknown

• 1 other identifier: UBMarginalBoneLossStudy
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

The impact of smoking on dental implant failure has been a constant topic of discussion for the past decade and the current literature confronts the inconclusive evidence of tobacco for a marginal bone loss risk factor. The aim of the present investigation is to determine the association between tobacco and marginal bone loss or implant failure in a sample of patients who had received implant-supported restorative therapy in the Dentistry Hospital of the University of Barcelona (Campus of Bellvitge). Considering that peri-implant marginal bone is essential for dental implant success, in this study we would like to establish the relationship between marginal bone loss around implants and smoking, in our own population study, in order to improve the prognosis of implant success in smoking patients. On the other hand, knowing the negative effect tobacco has on marginal bone loss in dental implants, we will be able to better predict peri-implant bone loss and reveal the probability of implant failure in short and long-term in smokers. By informing the patient correctly, we can raise awareness and create an additional reason for them to stop smoking, or at least reduce the number of cigarettes they smoke per day.

Conditions

Dental Implant Failed; Marginal Bone Loss; Smoking

Keywords

Dental Implant

Outcome Measures

Primary Outcomes (1)

• Marginal bone loss measured on Periapical Radiography

  Marginal bone loss (MBL) around dental implants

  60 minutes

Study Arms (2)

Smoking Patients with Dental Implantes

Smoking Patients rehabilitated with dental implants at the Dentistry Hospital of the University of Barcelona (Campus of Bellvitge).

Diagnostic Test: Radiographic study

Non-Smoking Patients with Dental Implantes

Non-Smoking Patients rehabilitated with dental implants at the Dentistry Hospital of the University of Barcelona (Campus of Bellvitge).

Diagnostic Test: Radiographic study

Interventions

Radiographic study DIAGNOSTIC_TEST

Candidates undergo a radiographic study (Orthopantomography and Implant periapical radiography)

Non-Smoking Patients with Dental Implantes; Smoking Patients with Dental Implantes

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients provided with implant-supported restorative therapy selected from the Dentistry Hospital of the University of Barcelona database.

You may qualify if:

• Patients with a Smoking Habit
• Patients 20 - 80 years old
• Patients rehabilitated at DHUB
• Patients with a radiographic record at the time of implant loading
• Patients rehabilitated with one or more dental implants

You may not qualify if:

• Patients with untreated periodontal disease
• Patients with uncontrolled systemic pathology
• Pregnant women or in lactation
• Patients treated with antiresorptive drugs
• Patients without radiographic records

Sponsors & Collaborators

• University of Barcelona: lead

Study Sites (1)

Hospital Odontologico de Bellvitge

Barcelona, 08907, Spain

RECRUITING

Related Publications (9)

• Kumar A, Nasreen S, Bandgar S, Bhowmick D, Vatsa R, Priyadarshni P. Comparative Evaluation of Marginal Bone Loss and Implant Failure Rate in Smokers and Nonsmokers. J Pharm Bioallied Sci. 2021 Jun;13(Suppl 1):S203-S206. doi: 10.4103/jpbs.JPBS_676_20. Epub 2021 Jun 5.

  PMID: 34447076 BACKGROUND

• Naseri R, Yaghini J, Feizi A. Levels of smoking and dental implants failure: A systematic review and meta-analysis. J Clin Periodontol. 2020 Apr;47(4):518-528. doi: 10.1111/jcpe.13257. Epub 2020 Feb 7.

  PMID: 31955453 BACKGROUND

• Linkevicius T, Linkevicius R, Gineviciute E, Alkimavicius J, Mazeikiene A, Linkeviciene L. The influence of new immediate tissue level abutment on crestal bone stability of subcrestally placed implants: A 1-year randomized controlled clinical trial. Clin Implant Dent Relat Res. 2021 Apr;23(2):259-269. doi: 10.1111/cid.12979. Epub 2021 Feb 2.

  PMID: 33527729 BACKGROUND

• Nazeer J, Singh R, Suri P, Mouneshkumar CD, Bhardwaj S, Iqubal MA, Dinesh. Evaluation of marginal bone loss around dental implants in cigarette smokers and nonsmokers. A comparative study. J Family Med Prim Care. 2020 Feb 28;9(2):729-734. doi: 10.4103/jfmpc.jfmpc_1023_19. eCollection 2020 Feb.

  PMID: 32318410 BACKGROUND

• Badenes-Catalan J, Pallares-Sabater A. Influence of Smoking on Dental Implant Osseointegration: A Radiofrequency Analysis of 194 Implants. J Oral Implantol. 2021 Apr 1;47(2):110-117. doi: 10.1563/aaid-joi-D-19-00223.

  PMID: 32699886 BACKGROUND

• Raes S, Rocci A, Raes F, Cooper L, De Bruyn H, Cosyn J. A prospective cohort study on the impact of smoking on soft tissue alterations around single implants. Clin Oral Implants Res. 2015 Sep;26(9):1086-90. doi: 10.1111/clr.12405. Epub 2014 May 5.

  PMID: 24798293 BACKGROUND

• Mumcu E, Beklen A. The effect of smoking on the marginal bone loss around implant-supported prostheses. Tob Induc Dis. 2019 May 20;17:43. doi: 10.18332/tid/109279. eCollection 2019.

  PMID: 31516486 BACKGROUND

• Javed F, Rahman I, Romanos GE. Tobacco-product usage as a risk factor for dental implants. Periodontol 2000. 2019 Oct;81(1):48-56. doi: 10.1111/prd.12282.

  PMID: 31407428 BACKGROUND

• Keenan JR, Veitz-Keenan A. The impact of smoking on failure rates, postoperative infection and marginal bone loss of dental implants. Evid Based Dent. 2016 Mar;17(1):4-5. doi: 10.1038/sj.ebd.6401144.

  PMID: 27012564 BACKGROUND

MeSH Terms

Conditions

Smoking

Condition Hierarchy (Ancestors)

Behavior

Central Study Contacts

Lina Dumanova

CONTACT

+34633840676; linadumanova@mail.ru

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 12, 2022
• First Posted: May 25, 2022
• Study Start: February 21, 2022
• Primary Completion: May 25, 2022
• Study Completion: June 5, 2022
• Last Updated: May 25, 2022

Record last verified: 2022-05

Locations

ES (1)