Evaluation of the Effects of Medicaments Used After Free Gingival Graft on Postoperative Complications.
1 other identifier
observational
60
1 country
1
Brief Summary
In our study, three different medicaments were evaluated in terms of postoperative complications after free gingival grafting (FGG).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Mar 2019
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 5, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 15, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
March 15, 2022
CompletedFirst Submitted
Initial submission to the registry
May 18, 2022
CompletedFirst Posted
Study publicly available on registry
May 23, 2022
CompletedMay 23, 2022
May 1, 2022
3 years
May 18, 2022
May 18, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Landry's Wound Healing Index (WHI)
WHI was performed on the basis of postoperative healing characteristics categorized as tissue color, response to palpation, incision margins, and suppuration.
21 days
Secondary Outcomes (5)
Visual Analogue Scale
21 days
Color match
21 days
delayed bleeding
21 days
burning sensation
21 days
complete epithelization
21 days
Study Arms (4)
Control
Patients were not given anything after FGG.
Flurbiprofen
Oral spray containing 0.075 g flurbiprofen administered after FGG
Hypochlorous acid
Oral spray containing hypochlorous acid applied after FGG
Hyaluronic acid
An oral spray containing the main component of the product is hyaluronic acid (sodium salt) with a high molecular weight of 30 mg / 100 g was given to patients after FGG
Interventions
Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva. After FGG, the patients were asked to apply this spray to the palatal mucosa 3 times a day.
Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva. After FGG, the patients were asked to apply this spray to the palatal mucosa 3 times a day.
Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva. After FGG, the patients were asked to apply this spray to the palatal mucosa 3 times a day.
Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva.
Eligibility Criteria
The population of the study consists of all patients, who were planned to be applied free gingival graft for mucogingival surgery
You may not qualify if:
- Pregnancy, lactation, and taking contraceptive pills.
- Oversensitivity or anaphylactic reactions which contraindicate the intervention.
- Orofacial neurological symptoms.
- Infections at operation zone.
- Psychotropic medicine, sedative, or non-steroid anti-inflammatory drugs use which can alter the sense of pain.
- Pathological mental conditions (dementia, psychosis) and lack of cooperation.
- Smoking
- Excessive gag reflex
- Operations are carried out with conscious sedation.
- Patients who do not want to sign consent.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Pamukkale University Faculty of Dentistry Department of Periodontology
Denizli, 20070, Turkey (Türkiye)
Related Publications (3)
Isler SC, Eraydin N, Akkale H, Ozdemir B. Oral flurbiprofen spray for mucosal graft harvesting at the palatal area: A randomized placebo-controlled study. J Periodontol. 2018 Oct;89(10):1174-1183. doi: 10.1002/JPER.17-0381. Epub 2018 Aug 29.
PMID: 30007054BACKGROUNDHassan A, Ahmed E, Ghalwash D, Elarab AE. Clinical Comparison of MEBO and Hyaluronic Acid Gel in the Management of Pain after Free Gingival Graft Harvesting: A Randomized Clinical Trial. Int J Dent. 2021 Aug 14;2021:2548665. doi: 10.1155/2021/2548665. eCollection 2021.
PMID: 34426739BACKGROUNDYildirim S, Ozener HO, Dogan B, Kuru B. Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner-masked, randomized, controlled clinical trial. J Periodontol. 2018 Jan;89(1):36-45. doi: 10.1902/jop.2017.170105.
PMID: 28914592BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
AYSAN LEKTEMUR ALPAN, PhD
Pamukkale Univesity
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- CROSS SECTIONAL
- Target Duration
- 2 Years
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Profesor
Study Record Dates
First Submitted
May 18, 2022
First Posted
May 23, 2022
Study Start
March 5, 2019
Primary Completion
March 15, 2022
Study Completion
March 15, 2022
Last Updated
May 23, 2022
Record last verified: 2022-05