NCT05386628

Brief Summary

In breast cancer patients, limitation of shoulder joint movement occurs following mastectomy surgery. Studies have reported that damage to the fascia on the pectoralis major muscle during mastectomy surgery contributes to the development of the limitation. The aim of this study is to investigate the effect of release techniques applied to the fascia on the pectoralis major muscle and the fascial chain on the incerasing of shoulder joint range of motion.

Trial Health

57
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
48

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Aug 2022

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 18, 2022

Completed
5 days until next milestone

First Posted

Study publicly available on registry

May 23, 2022

Completed
3 months until next milestone

Study Start

First participant enrolled

August 15, 2022

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 15, 2025

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

July 15, 2025

Completed
Last Updated

July 15, 2024

Status Verified

July 1, 2024

Enrollment Period

2.8 years

First QC Date

May 18, 2022

Last Update Submit

July 12, 2024

Conditions

Keywords

breast cancerrange of motionlymphatic drainage

Outcome Measures

Primary Outcomes (6)

  • measurement of tissue stiffness (N/m)

    Stiffness values will be measured with myotonPro on centers of coordination located along the myofascial chain .

    changes from baseline stiffness values will be measured at 6 week and 10 week

  • measurement of passive muscle tone (Hz)

    muscle tones will be measured with myotonPro on centers of coordination located along the myofascial chain

    changes from baseline tone values will be measured at 6 week and 10 week

  • measurement of creep of tissue

    creep of tissue will be measured with myotonPro on centers of coordination located along the myofascial chain

    changes from baseline creep values will be measured at 6 week and 10 week

  • measurement of the range of shoulder joint motion

    The range of shoulder flexion, abduction, extension and external-internal rotation movements will be measured with a universal goniometer.

    changes from baseline range of the shoulder joint motion values will be measured at 6 week and 10 week

  • assessment of activity of daily living

    upper extremity daily living functional capacity of participation will be assessed with the Quick-DASH (Shortened Disabilities Arm, Shoulder and Hand Questionnaire). The scale consists of 11 items. In the scale, a 5-point Likert scale is evaluated and scored 1-5. The scores that can be obtained from the scale are between 0-100. Lower scores indicate better daily activity participation.

    changes from baseline Quick-DASH Questionnaire scores will be assessment at 6 week and 10 week

  • assessment of depression and anxiety

    quality of life will be assessed using the Hospital Anxiety and Depression Scale (HAD). The scale consists of 14 items (7 items depression and 7 items anxiety). The scale is evaluated on a 4-point Likert scale and is scored 0-3. Depression and anxiety scores are calculated separately. While the score range that can be taken in the lower scales is 0-21, low scores are considered positive.

    changes from baseline HAD scale scores will be assessment at 6 week and 10 week

Secondary Outcomes (4)

  • measurement of skin temperature

    changes from baseline skin temperature values will be measured at 6 week and 10 week

  • measurement of pain

    changes from baseline pain values will be measured at 6 week and 10 week

  • measurement of pain pressure threshold

    changes from baseline pain pressure threshold values will be measured at 6 week and 10 week

  • measurement of grip strength

    changes from baseline grip strength values will be measured at 6 week and 10 week

Study Arms (4)

control group

ACTIVE COMPARATOR

Conventional physiotherapy program (joint movement exercises, local relaxation techniques, etc.) will be applied to the participants in this group.

Other: conventional physiotherapy

Manual lymphatic drainage group

EXPERIMENTAL

In addition to the conventional physiotherapy program, manual lymphatic drainage (including upper limb extremity and anterior/posterior axillar-axillar anastomoses and axilla-inguinal anastomosis) will be applied to the participants in this group.

Other: conventional physiotherapyOther: Manual lymphatic drainage

Myofascial relasing group

EXPERIMENTAL

In addition to the conventional physiotherapy program, myofascial chain relasing techniques will be applied to the participants in this group.

Other: conventional physiotherapyOther: Myofascial relasing

Lymphatic drainage and myofascial releasing group

EXPERIMENTAL

In addition to the conventional physiotherapy program, manual lymphatic drainage (including upper limb extremity and anterior/posterior axillar-axillar anastomoses and axilla-inguinal anastomosis) and myofascial chain relasing techniques will be applied to the participants in this group.

Other: conventional physiotherapyOther: Manual lymphatic drainageOther: Myofascial relasing

Interventions

A basic physiotherapy program consisting of shoulder exercises will be applied to the participants. content of the physiotherapy program * Shoulder passive/active abduction, flexion, internal and external rotation exercises * Posture exercises * Neck stretching exercises * Pectoralis major stretching exercises * Shoulder capsule stretching exercises * Scapular Mobilization exercises

Lymphatic drainage and myofascial releasing groupManual lymphatic drainage groupMyofascial relasing groupcontrol group

manual lymph drainage is a manual technique that is applied to the lymphatic system with a pressure of 40-50 mmHg and increases the working speed of lymphatic nodules/collectors. Manual lymph drainage will be made to the anterior axillar-axillar, posterior axillar-axillar and axilla-inguinal anastomosis collectors and the arm region (up to the elbow) lymph collectors.

Lymphatic drainage and myofascial releasing groupManual lymphatic drainage group

it will be done with the thumb or 3rd finger from the acu points of the superficial arm-anterior myofascial chain. 6-8 seconds with thumb to these points. pressure will be applied and vibration will be given clockwise.

Lymphatic drainage and myofascial releasing groupMyofascial relasing group

Eligibility Criteria

Age30 Years - 60 Years
Sexfemale(Gender-based eligibility)
Gender Eligibility Detailsbreast cancer survivors
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Women between the ages of 30-60
  • Having breast surgery within 2 years
  • Not have received conservative treatment for shoulder rehabilitation in the last 6 months
  • Having limitation of movement of the shoulder joint due to breast surgery

You may not qualify if:

  • Not having agreed to participate in the study
  • Having undergone radical mastectomy surgery
  • Having connective tissue disease
  • Presence of brachial plexus paresis/plegia
  • Presence of radiogenic fibrosis
  • Presence of additional orthopedic (scoliosis, etc.), neurological (multiple sclerosis, stroke, etc.) and rheumatological diseases (ankylosing spondylitis, rheumatoid arthritis, etc.) that will affect upper extremity functions
  • Presence of active metastases
  • Having undergone reconstruction surgery
  • Continuation of radiotherapy (must have ended at least 3 months ago) or chemotherapy applications
  • Having had a bilateral mastectomy
  • To develop lymphedema in the arm-trunk
  • Use of muscle relaxants
  • Patients with severe chemotherapy side effects (hyperesthesia, nausea, skin changes, weakness, etc.)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

İstanbul Medeniyet University

Istanbul, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Breast Neoplasms

Interventions

Manual Lymphatic Drainage

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

MassageTherapy, Soft TissueMusculoskeletal ManipulationsComplementary TherapiesTherapeuticsDrainagePhysical Therapy ModalitiesRehabilitation

Central Study Contacts

Nilüfer Kablan, PhD

CONTACT

Gülser Cinbaz, MSc

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Head of Department

Study Record Dates

First Submitted

May 18, 2022

First Posted

May 23, 2022

Study Start

August 15, 2022

Primary Completion

June 15, 2025

Study Completion

July 15, 2025

Last Updated

July 15, 2024

Record last verified: 2024-07

Data Sharing

IPD Sharing
Will not share

Available IPD Datasets

Individual Participant Data Set (26079868)Access
Individual Participant Data Set (16225693)Access
Individual Participant Data Set (12924842)Access
Individual Participant Data Set (31864435)Access
Individual Participant Data Set (22018755)Access
Individual Participant Data Set (18192154)Access
Individual Participant Data Set (25977305)Access
Individual Participant Data Set (20068255)Access

Locations