miRNA in Patients With Thoracic, Abdominal and Intracranial Aneurysms

NCT05382611 | Completed

• 1 other identifier: IG144101
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

To assess the expression of miRNA in patients with TAA, AAA in aneurysmatic tissue and to compare this expression with the healthy tissue in the same patient. In the same cohort, to asses the presence of miRNA in plasma and to compare with the control group. Over the period of three years,to follow subjects in order to assess if the presence of certain miRNAs speeds up or slows down the progression of disease. In patients with intracranial aneurysms to detect miRNA in plasma especially in patients with familial occurrence.

Conditions

Vascular Aneurysm

Keywords

miRNA

Outcome Measures

Primary Outcomes (1)

• The comparison of miRNA in healthy and aneurysmatic tissue

  miRNA will be compared in blood and in healthy and aneurysmatic tissue using ngs

  2020 at end of trial

Study Arms (2)

Patients Controls

Control group

Diagnostic Test: ngs next generation sequencing

Patients with aneurysma

Patients with aneurysma

Diagnostic Test: ngs next generation sequencing

Interventions

ngs next generation sequencing DIAGNOSTIC_TEST

the samples from aneurysmatic tissue and healthy aortic tissue will be investigated using NGS

Patients Controls; Patients with aneurysma

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study group will be made up of 50 subjects followed for the diagnosis of AAA or TAA and 20 patients with intracranial aneurysm. The control group comprises 20 subjects in total and will be made up of patients who are treated for lipid metabolism disorder

You may qualify if:

• years of age or older
• Patient willing and able to sign clinical trial Informed Consent
• Patient with AAA or TAA who require an open surgical procedure, or patient with intracranial aneurysm indicated for radiological intervention

You may not qualify if:

• \. Patient with multiorgan failure

Sponsors & Collaborators

• Na Homolce Hospital: lead
• Czech Academy of Sciences: collaborator

Study Sites (1)

Na Homolce Hospital

Prague, 15030, Czechia

Location

Biospecimen

Retention: SAMPLES WITH DNA

Aneurysmatic tissue, healthy tissue and blood

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc.Prof

Study Record Dates

• First Submitted: May 16, 2022
• First Posted: May 19, 2022
• Study Start: May 19, 2018
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: May 19, 2022

Record last verified: 2022-05

Locations

CZ (1)