NCT05380765

Brief Summary

The overall objective of this project is to develop and obtain preliminary data on acceptability, feasibility, and initial efficacy of Native PATHS. This work is guided by the stage model guidelines for treatment development and adaptation 25. Stage 1a will occur in two sequential steps. First, the investigators will recruit youth who are in 5th - 8th grade and their family members (N=24, 12 youth, 12 adults 18+) to participate in three talking circle sessions to obtain feedback on the cultural adaptation and implementation of the treatment. Next, the investigators will conduct an open label pilot (N=9). Youth and their family members, (up to 3 per youth) will provide qualitative and quantitative feedback after each session. In Stage 1b, 60 youth will participate in a pilot randomized controlled trial, testing the efficacy of the newly created program (n=30) against a wait list control (WLC) condition (n=30). Ultimately, this program of research is expected to result in a well-specified, efficacious prevention program that could be readily disseminated and generalizable to other Indigenous populations with minimal adaptation.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jun 2024

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 22, 2022

Completed
27 days until next milestone

First Posted

Study publicly available on registry

May 19, 2022

Completed
2.1 years until next milestone

Study Start

First participant enrolled

June 17, 2024

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 31, 2025

Completed
Last Updated

June 5, 2024

Status Verified

June 1, 2024

Enrollment Period

12 months

First QC Date

April 22, 2022

Last Update Submit

June 4, 2024

Conditions

Outcome Measures

Primary Outcomes (27)

  • Past month alcohol use

    Respondents will be asked whether they have used alcohol in the past month (yes/no).

    Baseline

  • Past month alcohol use

    Respondents will be asked whether they have used alcohol in the past month (yes/no).

    End of treatment (up to 12 weeks following baseline)

  • Past month alcohol use

    Respondents will be asked whether they have used alcohol in the past month (yes/no).

    Six months following end of treatment

  • Past three-month alcohol use

    Respondents will be asked whether they have used alcohol in the past three months (yes/no).

    Baseline

  • Past three-month alcohol use

    Respondents will be asked whether they have used alcohol in the past three months (yes/no).

    End of treatment (up to 12 weeks following baseline)

  • Past three-month alcohol use

    Respondents will be asked whether they have used alcohol in the past three months (yes/no).

    Six months following end of treatment

  • Past month marijuana use

    Respondents will be asked whether they have used marijuana in the past month (yes/no).

    Baseline

  • Past month marijuana use

    Respondents will be asked whether they have used marijuana in the past month (yes/no).

    End of treatment (up to 12 weeks following baseline)

  • Past month marijuana use

    Respondents will be asked whether they have used marijuana in the past month (yes/no).

    Six months following end of treatment

  • Past three-month marijuana use

    Respondents will be asked whether they have used marijuana in the past three months (yes/no).

    Baseline

  • Past three-month marijuana use

    Respondents will be asked whether they have used marijuana in the past three months (yes/no).

    End of treatment (up to 12 weeks following baseline)

  • Past three-month marijuana use

    Respondents will be asked whether they have used marijuana in the past three months (yes/no).

    Six months following end of treatment

  • Past month cigarette smoking

    Respondents will be asked whether they have smoked cigarettes in the past month (yes/no).

    Baseline

  • Past month cigarette smoking

    Respondents will be asked whether they have smoked cigarettes in the past month (yes/no).

    End of treatment (up to 12 weeks following baseline)

  • Past month cigarette smoking

    Respondents will be asked whether they have smoked cigarettes in the past month (yes/no).

    Six months following end of treatment

  • Past three-month cigarette smoking

    Respondents will be asked whether they have smoked cigarettes in the past three months (yes/no).

    Baseline

  • Past three-month cigarette smoking

    Respondents will be asked whether they have smoked cigarettes in the past three months (yes/no).

    End of treatment (up to 12 weeks following baseline)

  • Past three-month cigarette smoking

    Respondents will be asked whether they have smoked cigarettes in the past three months (yes/no).

    Six months following end of treatment

  • Alcohol use intentions

    Respondent will be asked how often in the next month they think they will get drunk with friends and how often in the next month they would like to get drunk with friends, on a five-point scale from 0 (never) to 4 (10 or more times), where higher scores indicate more frequent intentions to use alcohol in the next month.

    Baseline

  • Alcohol use intentions

    Respondent will be asked how often in the next month they think they will get drunk with friends and how often in the next month they would like to get drunk with friends, on a five-point scale from 0 (never) to 4 (10 or more times), where higher scores indicate more frequent intentions to use alcohol in the next month.

    End of treatment (up to 12 weeks following baseline)

  • Alcohol use intentions

    Respondent will be asked how often in the next month they think they will get drunk with friends and how often in the next month they would like to get drunk with friends, on a five-point scale from 0 (never) to 4 (10 or more times), where higher scores indicate more frequent intentions to use alcohol in the next month.

    Six months following end of treatment

  • Cigarette smoking susceptibility

    Cigarette smoking intentions will be measured using the Susceptibility to Smoking measure, which includes four items that asking respondents the likelihood that they will begin to smoke/experiment with cigarettes on a four-point scale from 0 (definitely not) to 3 (definitely yes), with higher scores indicating greater likelihood of intending to smoke cigarettes in the future.

    Baseline

  • Cigarette smoking susceptibility

    Cigarette smoking intentions will be measured using the Susceptibility to Smoking measure, which includes four items that asking respondents the likelihood that they will begin to smoke/experiment with cigarettes on a four-point scale from 0 (definitely not) to 3 (definitely yes), with higher scores indicating greater likelihood of intending to smoke cigarettes in the future.

    End of treatment (up to 12 weeks following baseline)

  • Cigarette smoking susceptibility

    Cigarette smoking intentions will be measured using the Susceptibility to Smoking measure, which includes four items that asking respondents the likelihood that they will begin to smoke/experiment with cigarettes on a four-point scale from 0 (definitely not) to 3 (definitely yes), with higher scores indicating greater likelihood of intending to smoke cigarettes in the future.

    Six months following end of treatment

  • Marijuana use intentions

    Respondent will be asked how often in the next month they think they will use marijuana with friends and how often in the next month they would like to use marijuana with friends, on a five-point scale from 0 (never) to 4 (10 or more times), where higher scores indicate more frequent intentions to use marijuana in the next month.

    Baseline

  • Marijuana use intentions

    Respondent will be asked how often in the next month they think they will use marijuana with friends and how often in the next month they would like to use marijuana with friends, on a five-point scale from 0 (never) to 4 (10 or more times), where higher scores indicate more frequent intentions to use marijuana in the next month.

    End of treatment (up to 12 weeks following baseline)

  • Marijuana use intentions

    Respondent will be asked how often in the next month they think they will use marijuana with friends and how often in the next month they would like to use marijuana with friends, on a five-point scale from 0 (never) to 4 (10 or more times), where higher scores indicate more frequent intentions to use marijuana in the next month.

    Six months following end of treatment

Study Arms (2)

Native PATHS Condition

EXPERIMENTAL

A strengths-based, behavioral economic approach to increasing engagement and reinforcement for engaging in alternative activities.

Behavioral: Native PATHS

Wait-List Control

NO INTERVENTION

Participants will receive the Native PATHS program once 6-month follow up surveys have been completed.

Interventions

Native PATHSBEHAVIORAL

A strengths-based, behavioral economic approach to increasing engagement and reinforcement for engaging in alternative activities.

Native PATHS Condition

Eligibility Criteria

Age10 Years - 14 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • residing in the First Nation community,
  • identify as a member of a First Nation,
  • be in grades 5th - 8th at time of enrollment, and
  • one youth per household may participate.
  • at least 18 years of age
  • reside within the First Nation community
  • be identified, by the youth, as an important influence in their life
  • be committed to helping the youth make good decisions regarding using substances

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Rhode Island

Kingston, Rhode Island, 02881-1967, United States

RECRUITING

MeSH Terms

Conditions

Alcohol DrinkingTobacco Use

Condition Hierarchy (Ancestors)

Drinking BehaviorBehavior

Study Officials

  • Nichea S Spillane, Ph.D.

    University of Rhode Island

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Nichea S Spillane, Ph.D.

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: wait-list control
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 22, 2022

First Posted

May 19, 2022

Study Start

June 17, 2024

Primary Completion

May 31, 2025

Study Completion

May 31, 2025

Last Updated

June 5, 2024

Record last verified: 2024-06

Data Sharing

IPD Sharing
Will not share

Locations