Short-course Antibiotic Treatment in AECOPD: a Meta-analysis of Double-blind Studies

NCT05380375 | Unknown DMC

• 1 other identifier: Meta analysis
• Study Type: observational
• Target: 2
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic obstructive pulmonary disease (COPD) is a common disease worldwide and a leading cause of death and disability globally. Given that bacteria are implicated in a substantial proportion of acute exacerbation of COPD (AECOPD), antibiotics are frequently used. However, this current practice may lead to antibiotic overuse further increasing drug resistance and side effects. Although the small literature on interventions to prove the effective of short course of antibiotic, a metaanalysis of published randomised double-blind studies comparing the same antibiotics compared to a previous study is performed to determine whether a short course of antibiotic treatment is as effective as a very short course in patients with an exacerbation of COPD (EACOPD). The authors systematically searched electronic databases on the literature of controlled trials on Medline and Embase with no language, location, or time restrictions. The authors retrieved observational and controlled trials comparing different durations of the same oral antibiotic therapy in the treatment of acute exacerbations of COPD. The authors included 30 randomized, placebo-controlled trials for COPD patients. There was no statistically significant difference between shorter and longer antibiotic courses in early clinical success. In conclusion, Short-course antibiotic treatment is as effective as very short-course treatment in patients with mild to moderate exacerbations of chronic bronchitis and COPD.

Conditions

COPD Exacerbation

Keywords

AECOPD; antibiotic treatment; meta analysis; short course; Forest plot

Outcome Measures

Primary Outcomes (1)

• Clinical success

  clinical cure at early follow-up

  30 days

Study Arms (2)

Short-course

Group with short treatment of antibiotic of \<= 5 days

Very short-course

Group with short treatment of antibiotic of \<= 3 days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We searched on the literature of controlled trials on Medline and Embase using the following search terms: COPD, antibiotic treatment and clinical trials. We also searched the reference lists of included studies for additional studies.

You may not qualify if:

• Studies not published in the English language or with more than two or different antibiotics were excluded

Sponsors & Collaborators

• University of Monastir: lead

Study Sites (1)

Semir Nouira

Monastir, 5000, Tunisia

Location

Related Publications (1)

• Messous S, Rekik A, Keraani L, Hamed R, Toumia M, Dhaoui R, Sekma A, Ali KBH, Sassi S, Kouraichi C, Boukef R, Bouida W, Boubaker H, Msolli MA, Nouira S. Comparative Efficacy and Safety of Short- Versus Standard-course Fluoroquinolone Treatment in Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Meta-analysis of Double-blind Studies. Clin Ther. 2025 Aug;47(8):631-637. doi: 10.1016/j.clinthera.2025.04.020. Epub 2025 May 25.

  PMID: 40414751 DERIVED

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professeur

Study Record Dates

• First Submitted: May 7, 2022
• First Posted: May 18, 2022
• Study Start: February 24, 2022
• Primary Completion: March 5, 2023
• Study Completion: May 8, 2023
• Last Updated: August 17, 2022

Record last verified: 2022-08

Locations

TU (1)