Physical Activity and Mortality in Type 2 Diabetes

NCT05380232 | Completed

• 1 other identifier: 29717
• Study Type: observational
• Target: 502,682
• Locations: 0 countries
• Sites: N/A

Brief Summary

The primary aim of study is to study the association between leisure-time physical activity and all-cause mortality among individuals with type 2 diabetes in the UK Biobank cohort and the China Kadoorie Biobank cohort. Secondary outcomes are CVD-mortality (both cohorts) and risk of major adverse cardiovascular events (UK Biobank only). Secondary exposures are physical activity from transportation and occupation.

Conditions

Diabetes Mellitus, Type 2

Outcome Measures

Primary Outcomes (2)

• All-cause mortality

  Mortality status optained from registries. The longest available follow-up from baseline examination will be used. Deaths during the first 3 years will be left-censored.

  Through longest available follow-up, up to 14.5 years (UK Biobank)

• All-cause mortality

  Mortality status optained from registries. The longest available follow-up from baseline examination will be used. Deaths during the first 3 years will be left-censored.

  Through longest available follow-up, up to 12.4 years (China Kadoorie Biobank)

Secondary Outcomes (2)

• Cardiovascular mortality

  Through longest available follow-up, up to 14.5 (UK Biobank) and 0.4 (China Kadoorie Biobank) years

• Major adverse cardiovascular events (MACE)

  Through longest available follow-up, up to 14.5 (UK Biobank only)

Study Arms (1)

Individuals with type 2 diabetes at the baseline examination

UK Biobank: Prevalent type 2 diabetes is determined by the algorithm of Eastwood et al. (6) or from measured Hba1c ≥48 mmol/mol. China Kadoorie Biobank: prevalent type 2 diabetes is based on self-reported current diabetes with a diagnosis age above 30 years, a random plasma blood glucose ≥11.1 mmol/L, or fasting plasma blood glucose ≥7.0 mmol/L.

Behavioral: Leisure-time physical activity

Interventions

Leisure-time physical activity BEHAVIORAL

Self-reported leisure-time physical activity, categorized as; zero (reference), \>0-7.49 MET-hrs/week, 7.5-14.9 MET-hrs/week, or ≥15 MET-hrs/week.

Individuals with type 2 diabetes at the baseline examination

Eligibility Criteria

• Age: 30 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

See statistical analysis plan

You may qualify if:

• UK Biobank: Prevalent type 2 diabetes is determined by the algorithm by Eastwood (PMID: 27631769) or from measured Hba1c ≥48 mmol/mol.
• China Kadoorie Biobank: Self-reported current diabetes with a diagnosis age above 30 years, a random plasma blood glucose ≥11.1 mmol/L, or fasting plasma blood glucose ≥7.0 mmol/L

You may not qualify if:

• None

Sponsors & Collaborators

• Aarhus University Hospital: lead
• University of Aarhus: collaborator
• The Danish Diabetes Association: collaborator

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 5, 2022
• First Posted: May 18, 2022
• Study Start: March 1, 2006
• Primary Completion: October 1, 2021
• Study Completion: October 30, 2021
• Last Updated: May 18, 2022

Record last verified: 2022-05