Davos Alzheimer's Collaborative Study: Sequential Administration of Digital Testing To Screen For Cognitive Impairment Followed By Blood Based Biomarkers To Assist With Timely Detection And Accurate Diagnosis Of Alzheimer's Disease

NCT05379348 | Completed

• 1 other identifier: 1811673
• Study Type: observational
• Target: 1,423
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate how we can detect Alzheimer's disease early by using an online memory test and a simple blood test. These new methods for early diagnosis could allow people to begin treatment sooner, with the potential to improve the lives of millions of people.

Conditions

Alzheimer Disease

Outcome Measures

Primary Outcomes (1)

• Quantify the proportion of individuals at least 65 years old with cognitive impairment

  Less than 6 months

Study Arms (3)

General study participants (patients)

Other: Cognitive Assessment

Healthcare Practitioners

Pre-Program Chart Audits (100 patients what will be chart audited)

Interventions

Cognitive Assessment OTHER

Montreal Cognitive Assessment - MoCA, which is a cognitive screening tool that assesses: memory, concentration, language, and orientation to time and place. this written cognitive test should take no more than 20 minutes.

Also known as: MoCA

General study participants (patients)

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy male and females ages \>65 years old.

You may qualify if:

• Subjects must meet the following criteria for entry into the study:
• Male or female \> 65 years of age at the time of consent;
• Understand and voluntarily sign an informed consent form;

You may not qualify if:

• Subjects who meet any of the following criteria will not be eligible for entry into the study:
• Subjects who are unable to hear and see well enough to complete the assessments;

Sponsors & Collaborators

• AdventHealth Translational Research Institute: lead
• Davos Alzheimer's Collaborative: collaborator

Study Sites (1)

AdventHealth Translational Research Institute

Orlando, Florida, 32804, United States

Location

Related Links

• Related Info

MeSH Terms

Conditions

Alzheimer Disease

Interventions

Mental Status and Dementia Tests

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Neuropsychological Tests; Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Steven Smith, MD

  Study PI

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 13, 2022
• First Posted: May 18, 2022
• Study Start: March 14, 2022
• Primary Completion: August 5, 2025
• Study Completion: August 5, 2025
• Last Updated: March 30, 2026

Record last verified: 2026-03

Locations

US (1)