An fNIRS Study of Motor Cortical Activation in Stoke Patients

NCT05376098 | Unknown

• 1 other identifier: haojunwei7
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators evaluate the activation and connectivity of patients' motor regions in the acute phase of ischemic stroke by fNIRS.

Conditions

Acute Ischemic Stroke

Keywords

Stroke; Motor rehabilitation; Brain regions; fNIRS

Outcome Measures

Primary Outcomes (4)

• fNIRS characteristics of upper limb movement

  The changes in brain oxygen levels are collected in two wavelengths, including 845 and 763 nanometers using a 44 channeled fNIRS machine. The data is used to determine the position of the activated area of the brain and functional connectivity during the movement. The locations of fNIRS channels on the skull of individuals are determined due to the observations on the cortical regions of interest (ROIs), namely the contralateral sensorimotor cortex (SMC), the contralateral premotor cortex (PMC) and primary motor cortex (M1), etc.

  0-14 day

• Assessment of upper limb function

  Recording the quality and frequency of fNIRS motion tasks including grip and reach-out movements.

  0-14 day

• Assessment of upper limb function

  Evaluating the motor function by Action Research Arm Test.

  0-14 day

• Assessment of upper limb function

  Evaluating the motor function by Fugl-meyer assessment.

  0-14 day

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with acute ischemic stroke with upper limb motor dysfunction diagnosed and treated by the Xuanwu Hospital Capital Medical University.

You may qualify if:

• The diagnosis of ischemic stroke should meet the diagnostic criteria of the "China Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018".
• years old≤ age ≤ 75 years old.
• Cerebral ischemic stroke onset within 7 days.
• First onset.
• Upper limb motor dysfunction.

You may not qualify if:

• Unstable vital signs.
• Complicated with other diseases in the nervous system.
• Combined with other serious disease states: circulatory system, respiratory system,
• motor system diseases, such as atrial fibrillation, heart failure, lung infection, severe liver and kidney dysfunction, lower limb venous thrombosis, etc.
• Upper limb dysfunction caused by other reasons, such as fractures, upper limb deformities, etc.
• Contraindicated to imaging tests, such as metal implantation, claustrophobia, and severe obesity.
• Those who cannot complete the examination due to other reasons, such as mental disorders, cognitive dysfunction, etc.
• Other causes: alcoholism; pregnancy; skull defects; soft tissue injuries at the site of examination; visual impairment, etc.

Sponsors & Collaborators

• Xuanwu Hospital, Beijing: lead

Study Sites (1)

Xuanwu Hospital, Capital Medical University

Beijing, China

RECRUITING

MeSH Terms

Conditions

Ischemic Stroke; Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Junwei Hao

  Xuanwu Hospital, Beijing

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Junwei Hao

CONTACT

010-83199088; haojunwei@vip.163.com

haijie Liu

CONTACT

+86 15822841534; haijieliu@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 1, 2022
• First Posted: May 17, 2022
• Study Start: February 1, 2022
• Primary Completion: July 1, 2024
• Study Completion: July 31, 2024
• Last Updated: May 17, 2022

Record last verified: 2021-12

Locations

CN (1)