NCT05374460

Brief Summary

How participants perceive the position of their own hand in various contexts will be examined. This will include changing the visual display to suggest the hand is in a slightly different position, and asking participants to indicate where they think it is by pointing with their other hand.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
300

participants targeted

Target at P75+ for not_applicable

Timeline
12mo left

Started Apr 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress80%
Apr 2022Apr 2027

Study Start

First participant enrolled

April 29, 2022

Completed
11 days until next milestone

First Submitted

Initial submission to the registry

May 10, 2022

Completed
6 days until next milestone

First Posted

Study publicly available on registry

May 16, 2022

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2027

Last Updated

August 26, 2025

Status Verified

August 1, 2025

Enrollment Period

5 years

First QC Date

May 10, 2022

Last Update Submit

August 20, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Realignment

    Measured by comparing where the subject points on a touchscreen when indicating perceived position of visual and proprioceptive targets early vs. late in the behavioral task.

    1 day

Secondary Outcomes (2)

  • Visuo-proprioceptive weighting

    1 day

  • Target estimation variance

    1 day.

Study Arms (6)

Conscious awareness: No information

SHAM COMPARATOR

Told nothing about the visuo-proprioceptive mismatch. Hand remains hidden beneath mirror that shows visual display. (control)

Behavioral: Attend to the targets

Conscious awareness: Explanatory diagram

EXPERIMENTAL

Told in advance about the visuo-proprioceptive mismatch, which will be explained with a diagram. Hand remains hidden.

Behavioral: Explanatory diagram

Conscious awareness: Direct vision of hand

EXPERIMENTAL

Foamboard under mirror removed, making the mirror see-through and the hand directly visible.

Behavioral: Direct vision

Movement feedback: No feedback

SHAM COMPARATOR

No movement feedback (control)

Behavioral: No movement feedback

Movement feedback: Target hand

EXPERIMENTAL

Movement feedback about the target hand.

Behavioral: Movement feedback, target hand

Movement feedback: Pointing hand

EXPERIMENTAL

Movement feedback about the pointing hand.

Behavioral: Movement feedback, pointing hand

Interventions

Participant is told there will be a mismatch between their target finger and the visual indicator of target finger position. They will be shown a diagram explaining this.

Conscious awareness: Explanatory diagram
Direct visionBEHAVIORAL

Foamboard under mirror removed, making the mirror see-through and the hand directly visible. Mismatch between target hand and visual indicator will be directly visible.

Conscious awareness: Direct vision of hand

After the participant points at each target, a cursor indicating final pointing position will be displayed briefly. The visual indicator of the target hand will be displaced.

Movement feedback: Target hand

After the participant points at each target, a cursor indicating final pointing position will be displayed briefly. The visual indicator of the target hand will not change, but the cursor indicating pointing hand position will change.

Movement feedback: Pointing hand

The visual indicator of the target hand will be displaced, but there will be no cursor to indicate the pointing hand's position.

Movement feedback: No feedback

Participants will not be told anything about the visuo-proprioceptive mismatch. Instead, they will be asked simply to attend to the target positions.

Conscious awareness: No information

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Between the ages of 18-45 years old
  • Right-handed.
  • Covid has been found to have neurological effects in some people, but mostly the effects on sensorimotor control and neurophysiology are unknown. So we will only include individuals who report being free of Covid symptoms in week preceding testing.

You may not qualify if:

  • Past or present history of seizure, stroke, any brain or peripheral nerve disease, severe head trauma, or spinal cord surgery.
  • Learning or attention conditions such as ADHD.
  • Orthopedic or pain conditions, or a history of seriously injured bones, joints or muscles in either arm.
  • Lack of normal or corrected-to-normal vision.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hannah Block

Bloomington, Indiana, 47403, United States

RECRUITING

Study Officials

  • Hannah J Block

    Indiana University, Bloomington

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Hannah J Block, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

May 10, 2022

First Posted

May 16, 2022

Study Start

April 29, 2022

Primary Completion (Estimated)

April 30, 2027

Study Completion (Estimated)

April 30, 2027

Last Updated

August 26, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will share

All IPD that underlie results published in peer-reviewed journals will be shared. Only de-identified data will be shared.

Shared Documents
ANALYTIC CODE
Time Frame
The data will become available when group results are published in peer-reviewed journals.
Access Criteria
Data will be available on www.osf.io for anyone who wishes to download it. The relevant osf registry will be cited in the peer-reviewed publication so that interested readers can find it.

Locations